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Disappointed with Springfield's snooty, glitzy L.A. Body Works gym, Marge opens her own facility for ''real women" called "Shapes". Meanwhile, the kids of Springfield go to a new comic book store where the clerk (a man named Milo) is nicer than The Android Dungeon's Comic Book Guy, and Homer becomes obsessed with getting plastic surgery.
In the opening sequence, Bart is writing "The pilgrims were not illegal aliens" on the board.
Couch: A pair of cartoon hands opens up a book called "The Simpsons" and reveals a pop-up centerfold of the family sitting on the couch.
Bart: You should stop being so mean to us kids.
Comic Book Guy: Well, I suppose you could buy some comics at the dry cleaners.
(Comic Book Guy has just noticed a new comic store that has opened up across the street.)
Comic Book Guy: Philip K Dick! It can't be! It's as if Superman moved to Gotham City!
Martin: Which he did, in World's Finest Comics #94. (Points to the comic.) See?
Comic Book Guy: That was an imaginary story, dreamt by Jimmy Olsen after he was kicked in the head by Supergirl’s horse, Comet. It never really happened.
Bart: None of these things ever really happened.
Comic Book Guy: Get out of my store.
Comic Book Guy: Nice work, Doctor Boo-Who. Your tears have smudged Wolverine's iconic sideburns. Hence, you must buy this comic. And the cost of your innocnet accident is... 25 dollars, please.
Milhouse: But that's the money Yaya Sophia gave me for Greek Orthodox Easter.
Comic Book Guy: (Sighs) I hate when they tell me things about themselves.
Lisa: I really identified with the girls in Ghost World. They made me feel like I wasn't so alone.
Dan Clowes: Yeah, yeah, whatever. Do you know anyone at Batman? 'Cause I really want to draw Batman, I'm awesome at utility belts. (points to a picture of a utility belt.)
Dan Clowes: Check these out. This is where the Batman keeps his money in case he has to take the bus.
There is a reference to OK Go's music video of Here it Goes Again.
This episode's title is a probable reference to 'Husbands & Wives', the 1992 Woody Allen movie.