First Episode to Air in High Definition.

This is the first episode since season two's "Bart Gets an F" to have a new opening sequence.

Blackboard: HDTV is worth every cent
Couch: The family rushes into the living room to discover that the couch is missing (similar to the couch gags in "Itchy & Scratchy & Marge" and "Sleeping With the Enemy"). Through the window, Homer spots the couch escaping down the road, and the family gives chase. The Simpsons follow the couch to various destinations throughout the world, such as the streets of San Francisco, the water canals of Venice and inside a palace room in India before finally catching up with it in outer space. Homer directs the couch towards Earth, and the family (dressed as astronauts like in the couch gag to "The Principal and the Pauper") crashes through the ceiling into the living room. Homer pulls out a remote from underneath him and turns on the TV, which is now a wall-mounted flatscreen TV that ends up falling to the floor.

Homer: Oh, I get it, you're all going to try to convince me that my life is great just like it is, right?
Lisa: Are you kidding? We couldn't even convince you that Bruce Wayne is Batman.
Homer: Oh, come on, that billionaire playboy. He's too busy socializing at cocktail parties and managing the affairs of the Wayne foundation
Marge: (whispering) Don't open this one again.
Lisa: Why does he think Alfred is friends with Batman?
Marge: Just stop.

(After it's learned in Homer's alternate reality that he and Marge wouldn't have Bart, Lisa, and Maggie)
Marge: Well that's what's missing. Our lives would be horrible without the kids.
Homer: Uh, yeah, that must be it. This is the best of all possible worlds. Blah, blah, blah and--I wanna live in the sauce!
(He jumps into the sauce pot, the Sauce Chef pulls him out)
Sauce Chef: If you could live in the sauce, don't you think I would live in the sauce?! Stupid!

Just like the season 14 episode, Brake My Wife Please, this episode's title is an allusion to 'Take My Wife, Please', the famous one-liner from comedian Henny Youngman (1906-1998)