The Tick is suddenly sporting a mustache, much to Arthur's concern. It turns out the mustache is a living weapon left over from the Cold War era that takes over the mind of its victims. Jim Rage and the ladies of Project: SHAVE come to The City in pursuit of the mustache.
In a plot to take over The City, Chairface Chippendale, switches Dinosaur Neil's anti-growth medication with placebos, and increases the amount of stress generated at his wedding by employing the services of El Seed to mutate the flower arrangements, and The Breadmaster, to plant a cake bomb. And then in one final plot, Chairface hires the Indigestible Man to plant the electronics he needs to take over Neil's body!
Arthur is on a date with Carmalita only her old baseball team, The Aztecs, try to kidnap her. They nab Arthur instead, so the Tick and Carmalita have to follow them to some Aztec ruins in Mexico. The Tick picks up a pet, "Speak" while he is there.
Baron Violent is tearing up The City, using his strength-enhancing belt. After he is defeated, Arthur begins using the belt but he succumbs to its influence towards making the user mean. The Tick has to stop Arthur at all costs!
Mr. Mental returns in this episode to steal a mind-altering device to animate his thoughts, the problem, he needs a place to build it. It makes perfect sense to live with the Tick. Using his mind powers, he makes the Tick think that he's a baby!
Sewer Urchin finally is the hero in this episode as he battles his arch enemy, Lou Salazar the Sewer Czar and his army of Filth!
The Tick switches places with Éclair, a superheroine from Belgium, in the name of international relations. The Breadmaster decides to take over The City with gingerbread men in the Tick's absence. Meanwhile, The Tick goes disco dancing in Belgium, with Éclair's sidekick, Blitzen and has to fight some European supervillains.
Chairface Chippendale plans to steal a body-switching device from a mad scientist convention by sending Professor Chromedome to do his dirty work. Through all the chaos that ensued in the acquisition of the device, The Tick wound up in a zebra, Arthur wound up in a giant tongue, and Chromedome wound up in the Tick. Chromedome ran back (in the Tick’s body) to Chairface in eight minutes flat (and lifted up a dump truck along the way) to the shock of his employer. Chairface then used the device to switch himself into the Tick's body and Chromedome into Chairface's.
The Tick and Arthur find themselves stuck in the past 3.5 million years ago! They join up with a tribe of apemen who are subsequently captured and forced to work in a hotel by the owner, a humanoid from the distant future.
The Tick is teaching a class of student super heroes when a company mascot named Uncle Creamy begins to exact revenge against his former employer, the local ice cream factory for accidentally turning him into a living ice cream cone. The company hires a second mascot to replace and fight Uncle Creamy and the Tick and his class get involved.