When a crazed man attempts to start a war between the United States and Mexico by burning and looting towns along the border, Ulysses S. Grant dispatches two special agents: James T. West (Robert Conrad) and Artemus Gordon (Ross Martin), to try and prevent the war.
West tries to meet with Captain Jackson, who has discovered something that imperils the nation. After some difficulty, West finds the man seconds before a bomb kills him. West's only clue is the dying man's last word - "Flory" - and his concern over large amounts of coal.
Professor Neilsen has devised an extremely powerful explosive. West and Gordon must help him get to Washington with it, but twisted genius Dr. Miguelito Loveless has other plans. After Loveless kills the professor, West must track him down and learn his plans before a lot more people die.
Strange black clad figures form human ladders to climb walls and enter the United States mint at Carson City. They plant a bomb and then leave - without stealing any of the money! Jim West and Artemus Gordon must figure out why they broke in, and hope that answer leads to the person responsible before economic disaster befalls the United States!
John Maxwell Avery moved mountains in Washington. The president sought his advice and men followed him. Then he was discovered to be a ruthless political opportunist and an unprincipled scoundrel. He fled justice and has killed many men to keep his freedom. Some believe the President helped him escape. To prevent a scandal Avery must be returned alive to Washington – exactly the sort of job for Jim West and Artemus Gordon.
Riverboats plying the Mississippi disappear completely – only traces are ever found. Cargo and passengers disappear just as completely. Jim West and Artemus Gordon are the fifth and sixth men sent by the government to learn what has paralyzed boat traffic along a major waterway. If they can’t unravel the mystery they will meet the same watery deaths as the men who preceded them!
A glowing corpse and a secretary's ankle provide Jim and Artie with the only clues to the theft of radioactive material.
Jim and Artie must ensure that Princess Gina of Albania reaches her destination. The coach bearing Her Highness arrives and she disembarks... and Ambassador Perkins realizes the woman is an imposter! To prevent a diplomatic incident, Jim and Artie must determine who has kidnapped or killed the Princess, and if she is still alive, rescue her.
The Central and Western Railroad faces trouble. Indians have demanded $500,000 in gold or they will continue their slaughter of the work crews building the railroad. Five men will die each day until they money is paid – or James West and Artemus Gordon put a stop to the murders. The leader of the Indians, American Knife, proves elusive – until he wishes to be seen.
An intriguing woman Jim meets in a restaurant leads to a coach ride – and a generous dose of anesthetic gas, courtesy of an old enemy who plans to destroy James West and the Secret Service, a good piece of Washington, D.C. and regain a lost heritage! If the plan succeeds, James West will do this madman’s bidding, while James West lies under a cold granite headstone...
The fiancé of a senator's niece disappears and Jim is sent to investigate. He finds a secret military base run by a general who offers equality to men and women... and plans to conquer the Southwest U.S.
Earthquakes have destroyed the Wyoming towns of Twin Rivers and Crown Point. Before the quake, fliers predicting it circulated in each town. Now similar fliers have convinced most residents of Sentinel to flee. Jim and Artie arrive in two, and once again an earthquake strikes. They must discover who can create earthquakes on demand and how he does it, before the entire Wyoming territory collapses into rubble!
Jim and Artie receive a telegram from President Grant. Governor Bradford has requested help thwarting a conspiracy against his life. When Jim and Artie arrive, the governor and his assistant confirm the plot and request the agents guard the governor until he can bring his own resources against the conspirators. Strangely, in the span of a few hours assassins make two attempts on Jim’s life and none on the governor’s life. And what is it about the painting hanging behind the governor’s desk that disturbs Jim? The agents must uncover an evil man with an artist’s gift for skulduggery before he can complete an audacious scheme to ensure his posterity at the expense of the state coffers!
Shortly after returning from Washington with a vitally important message from President Grant to Chief Ho-Tami, James West receives a telegram calling him to the Samaritan Hospital, where his friend and fellow agent Artemus Gordon lays gravely injured. Arriving, Jim sees a doctor cover a body with the sheet, but when Jim examines the body, a plume of gas knocks him cold! It’s all part of a sinister scheme to ensure that Jim West delivers a message of an entirely different sort to the chief – a message that will ensure bloodshed for years to come! If Dr. Arcularis can bend Jim to his will, the agent will murder the chief, very publicly, setting off a war between the United States and an army of Indians a hundred thousand strong!
Colonel Vasquez has his men rob American banks and flee across the American/Mexican border. The local law can't pursue them, so Jim and Artie come to put an end to his operation. Jim goes undercover as wanted outlaw Frank Slade and Artie as his down-on-his-luck friend Mohave Mike. But when Jim arrives at Vasquez' headquarters, he realizes he knows Vasquez' girlfriend Linda Medford from a previous case, and she knows him!
An ex-Army colonel crippled by an explosion rebuilds his body using metal parts. Then he begins killing the men he holds responsible for his misery... and one of them is President Grant!
The agents become involved with rival Tongs when a British Colonel plans to use a missing Chinese Princess as a figurehead for him to take the Emperor's throne.
Jim and Artie are looking for stolen kerosene and copper ingots, but the trail leads to a weapon capable of shooting fireballs, owned by... abolitionist John Brown, reported as hung by the neck years previously.
Jim and Artie are assigned to protect a visiting dignitary, the Emir El Emid. The Emir is unaware that the League of Assassins have targeted him and their primary killer, Ecstasy La Joie, has an exploding garter, a poisonous ring, and a razor-sharp tambourine at her disposal.
Dr. Loveless has engineered the bankruptcy of California, forcing its governor to grant prestige and respectability to three disreputable businessmen types in return for their paying off their debt. Now Loveless plans to capture the three businessmen, keep the money, and get himself elected Governor of California.
Jim and Artie investigate a series of murders commited by puppets, and find themselves in a vast underground kingdom occupied by man-sized puppets and ruled by the maniacal Zachariah Skull.
When an outlaw band pillages nearby towns, Jim and Artie check out a prison that appears to be at the center of the operations. Posing as a prison inspector, Jim goes in to investigate and soon discovers that everything is not what it seems.
Jim and Artie have to guard a South Pacific prince who wants to go to a spa, unaware that assassins are planning on killing him.
A professor, Jim's close friend, is incinerated in a bizarre accident, and an influential Senator thwarts West's investigation. The trail leads to a magician named Asmodeus and a series of bizarre thefts from the corpses of geniuses.
Ex-Army ordinance officer Thorald Wolfe plans the conquest of Baja California using explosive bullets and a prototype tank, and Jim and Artie must infiltrate his organization and stop him.
Jim is framed for an impossible jewelry theft and it turns out the real thief has developed a potion that lets him move so fast that he's invisible... and unstoppable.
Jim arrive in town to capture Dr. Loveless, but suffers from searing head pains. He begins to see Loveless everywhere, and when Artie gets in his way... Jim ruthlessly guns him down.
Jim and Artie investigate a town where the people are paralyzed and discover that a gang is using a bacillus to aid them in their robberies.
A government agent turns up dead at a circus warehouse, and when Jim and Artie investigate they find themselves up against the Eccentrics, a band of trained assassins and performers led by the malevolent magician, Count Carlos Mario Vincenzo Robespierre Manzeppi.
An ex-maharjah builds a palace on a Pawnee Indian reservation and wants Jim West to train his sons... as killers.
An Indian princess is kidnapped and her abductor demands Jim and Artie come to rescue her. They find that Dr. Loveless is holding her prisoner, but his plan is far greater then mere ransom. He plans to miniaturize everyone in the world... and Jim West is his first victim.
During Mardi Gras in New Orleans, a female mad scientist creates robot duplicates of Jim and Artie to kill President Grant when he refuses to finance her experiments.
Jim and Artie are called in to help a rancher who it turns out is being haunted by the ghost of a Confederate colonel. The key to the hauntings lie with a stable boy, Jeremiah, who has a strange ability to control animals.
Jim and Artie suspect something is up when an alien spacecraft lands outside a small town playing host to a gold dust shipment and three attractive green-skinned women from Venus emerge... and ask for gold to replenish their fuel supply.
Jim and Artie go on vacation and pass through Justice, Nevada, where they are victims of a mock hanging in celebration of Law & Order Week. But matters take a turn for the worse when they discover that Lucrece Posey is using the town as cover to bring together a gang of ruthless criminals to form a worldwide criminal cartel.
Jim and Artie must free an undercover American agent from Devil's Island, and must cope with a fastidious Commandant, an iron-legged guard captain, and a treacherous woman.
Jim is lured to a tavern where he's darted unconscious by a mermaid, dumped on a ship, and witnesses a dragon swim through the water to explode and sink the vessel.
Jim and Artie check out Indian lands where the locals are acting strangely and plant life is mysteriously dying, and discover that they're under the command of an armored medieval knight! But it's their old nemesis Dr. Loveless with a new scheme to bring the world to its knees.
A greedy mortuary owner provides a unique service on the side: plastic surgery to disguise wanted criminals, complete with a corpse provided to account for their "deaths."
Jim and Artie escort a prisoner who escapes to an old abandoned house... that is haunted by the unseen spirit of a sobbing woman.
Jim and Artie have a fight and Jim guns down Artie. However, it soon becomes clear it's a plan to set up Jim as a murderer so that a secret organization that collects killers will approach him for recruitment.
A bomb maker, Zeno Baroda, has apparently stolen a crate of dynamite and is targeting the judge who paroled him, at a judges' convention. Jim and Artie have to stop the maker of the "infernal machines" before it's too late.
Artie disappears during a magic act, and the trail takes Jim to a crippled Southern officer... who wants to use his mastery of time travel to regain the use of his legs and ensure the South wins the Civil War.
Jim and Artie escort a munitions scientist to an estate where they find out he's a member of a tontine: the last man standing gets all the group's investment millions. Problem is, the house is a death trap and someone is killing off the tontine members one by one.
Count Carlos Mario Vincenzo Robespierre Manzeppi returns, looking for a small merchanical chicken that holds an ages-old secret: the Philosopher's Stone.
Jim and Artemus have to deliver a gift from the Sultan of Ramapur to President Grant: a sacred white elephant. But the elephant gets stolen en route by bandits, and Jim tracks it to a gypsy camp where he has to get it back before an international incident occurs.
A Russian count offers a captive American vice-consul in exchange for cousin, a paroled prisoner. When the prisoner is killed, Artie is forced to go in disguised as the man so that they can recover the vice-consul.
A homicidal matchmaker plans to conquer the U.S. and declare herself Empress by taking control of the assets of five rich industrialists by having them marry her agents and then kill them.
A megalomaniacal genius who uses a steam-powered wheelchair to propel himself and conserve brain power, matches wits with Jim and Artie, luring them to him by killing their friends and sending the agents fake newspaper in advance announcing his intentions.
When a series of tidal waves sweep across the Atlantic, James and Artemus meet with a oceanographer who knows the cause. When the man is killed, the agents set out to find his associate, who may know the secret of the person responsible for the devastation.
There's an impossible theft of closely-guarded rare jewels. Jim and Artie soon determine that Dr. Loveless is responsible. His newest gadget: a device that allows him to enter paintings and emerge any time he wishes.
Jim rides ahead to the town of Gibsonville, where President Grant will be dedicating a statue to a fellow soldier. Unfortunately Gibsonville is plagued by a string of broken-neck deaths as greedy townfolks hunt for a hidden treasure.
The assassination of a naval intelligence officer and the sinking of a frigate leads the agents to a Hawaiian expatriate who plans to kill King Kalakua and take control of the islands.
An ex-army sergeant promotes himself to General and plans revenge against President Grant by putting mind control crystals into convicted criminals... and Jim tries to infiltrate his organization.
Jim and Artie are charged with delivering an exiled royal and his daughter back to his home country to be crowned as king. However, a mysterious sorcerer with power over wolves wants to make sure that the person on the throne is subject to his mental influence.
Dr. Loveless' newest scheme involved staging bank heists and then burning the money. Jim and Artie get on his trail an discover that the bank robberies are simply training exercises, and the good doctor has much greater plans to create his own country within the U.S.
The U.S. Constitution has been stolen! A revolutionist, Victor Freemantle, has obtained it and plans to destroy it if the U.S. doesn't grant Texas' Panhandle Strip independence and pay him a $1 million ransom. Jim and Artie must take in an expert, Grigsby, to verify it and then find a way to recover it.
Jim and Artie go after Sean O'Reilley, a revolutionary who plans to take control of Canada with stolen munitions taken from an American fort that needs the weapons to defend itself from marauding Indians.
An assassin tries to kill President Juarez of Mexico... and Jim and Artie must get the man out of prison to find out who hired him, and why.
Dr. Loveless is dead! But his former associates want the key that's around his wrist, a key that leads to valuable files. Loveless' uncle Dr. Liebknicht can lead Jim and Artie to the files, but Jim has to keep him alive long enough to get there.
Jim and Artie are escorting a rare Arabian horse to President Juarez of Mexico, a gift from Grant. A legendary bandit, Sordo, steals the horse for himself and the agents have to track Sordo down. However, Jim is forced to ally with Sordo when anti-Juarez forces try to kill them both and take the horse.
The Americans are preparing to return an antique samurai sword to the Japanese when an unknown thief steals it. Jim and Artie have 24 hours to find it before diplomat relations between the two countries collapse and an emperor hostile to the U.S. takes power.
The agents' stopover in a town turns to tragedy when a popular rancher is murdered. Jim easily catches the killer and he is readily convicted and sentenced to hang. However, the agents soon suspect that things were too cut-and-dried and decide to investigate for themselves.
Jim and Artie are assigned to accompany a Mexican officer on a joint trip to recover a vast Aztec treasure hidden in Texas. But criminals infiltrate the expedition and the group soon finds themselves in the hands of the descendents of the ancient Aztecs.
Jim and Artie go after a counterfeit ring centered in Denver, and suspect that the director of the Denver Mint may be involved. But when Jim is attacked by a man wielding a candy-striped flamethrower, the trail leads them to a circus.
A criminal mastermind and explosives expert, "The Falcon," has created a huge falcon-shaped cannon and demands an exorbitant ransom so he won't destroy Denver. Jim and Artie infiltrate the Falcon's organization and discover that criminals from across the world have arrived to see the cannon's demonstration and bid on the weapon.
Jim and Artie arrive in the town of New Athens, where the townfolks are packing up and leaving because of the threat of an army of cut-throats who plan to attack the town under the command of the mysterious Mike Trayne.
A territorial governor declares martial law and uses his Black Legion to enforce his decrees. Grant sends Jim and Artie to arrest the man and bring him back to Washington.
Someone sets up Jim in a series of events intended to discredited him. Once the agent is fired from the Secret Service, the mysterious individual approaches Jim and offers him $100,000 to steal a valuable item from a 30' saltwater tank in an isolated laboratory.
Jim and Artie are charged with extraditing Count Draja back to his Bosnian homeland. While Jim rides with Draja across the desert and copes with a family looking to collect the reward on Draja, Artie disguises himself as Draja and finds himself "rescued" by men who want the $500,00 in loot that the count has buried somewhere in the vicinity.
To protect the Colorado governor, Jim and Artie join a wagon train. One of the passengers is a European assassin who likes to break the necks of his victims, and the agents have no idea which passenger is the killer.
A blood-and-guts general plans to pave his way to the Presidency by launching attacks on hostile Indian tribes. President Grant wants to stop the violence and sends Jim and Artie in to find out who is responsible and put a stop to the potential outbreak of war.
Jim and Artie investigate... a boll weevil smuggling operation? Unfortunately the insects pose a deadly threat to American cotton crops and if the smuggling operation isn't stopped, every cotton field in the U.S. will be destroyed within five years.
Jim and Artie are sent to investigate a series of bank robberies committed by the Viper Gang. Only one town in the area, Freedom, KS, hasn't been hit, and the agents soon figure that someone in town is the leader of the gang.
A young woman recruits Jim to help her father, Major Hazard, who was crippled by a sadistic camp commandant. Hazard and his men want revenge on the commandant, Mosely, but reluctantly give Jim the man's location... but Hazard has his own plans.
Jim finds himself stranded in the middle of the desert in the unknown town of Paradox, NV. As masked mannequins shoot at him and a mysterious woman appears and disappears, the agent begins to realize that the entire thing is part of a madman's twisted scheme for revenge.
The search for a missing scientist takes Jim and Artie into the Louisiana bayous. There they find voodoo ceremonies, zombies, a mad scientist, and a long-delayed wedding.
Jim is escorting a case of smallpox vaccine to a town suffering from an epidemic, but outlaws take it, wound him in the head, and leave him for dead. Suffering from amnesia, Jim stumbles into a nearby town where a saloon girl takes him under her wing. Meanwhile, the man behind the theft, Furman Crotty, uses the vaccine as leverage to get himself released from prison and demand a million dollars from the U.S. government.
Jim and Artie ride to Kansas to bring Senator Buckley back to Washington. However, they quickly discover that Buckley and his sons have barricaded their manor against a strange intruder capable of crushing a man with his bare hands.
An organ grinder tries to kill President Grant with a Gatling gun hidden in his musical instrument. He fails, and a trail of raisins leads Jim and Artie to a monastery vineyard that has been taken over by a ex-Union general who plans to take control of California.
The evil Baron Hinterestoisser plans to humiliate President Ulysses S. Grant by showing a fake kinetoscope film of Grant signing a shady deal with a foreign power. Hinterestoisser has the film hidden in the German embassy under heavy guard and only Jim and Artie can get to it.
A scientist and his daughter are kidnapped by a cavalry officer turned arms dealer who wants the scientist's "doomsday formula": a massive explosive that he can sell to the highest foreign bidder.
Investigating crooks who are driving off homesteaders, Jim and Artie are confronted by a steam-driven juggernaut. Artie impersonates a businessman and buys the land, luring the crooks into making him their next target.
A man Jim is assigned to meet mysteriously disappears at the Sedgewick Hotel. Jim and Artie determine he was suffering from a rare disease, and track him to the Sedgewick Manor, where a mysterious Dr. Maitland is working on a cure for a genetic disease that plagues the Sedgewick family.
A vial with a volatile germ is stolen and Jim and Artie track it to a party hosted by an eccentric millionaire, Rufus Kraus, with a penchant for lethal games. The germ will release at midnight and the agents have that long to find it and survive Kraus' "entertainment."
Jim and Artie meet with a Navy lieutenant to discuss what is threatening fishing in the area, but the man is killed... by a giant squid. Admiral Farragut is arriving in the area and the agents must determine what the monster is and who is responsible.
Norbet Plank, the chief bookkeeper of a syndicate, is wanted for murder and flees to his boss' company town. Jim and Artie must get into the town, find the man, and get him out in one piece.
Thieves steal the gem-eye of the statue of the Sun God Ra, setting off an international incident, and Jim and Artie have to recover it. But the gem has much more value then simply its monetary worth: it's the key to something even greater.
Jim and Artie are summoned to the deserted mining town of Brimstone by a Professor Colecrest, who has some secret to tell them. But the town has been taken over by Zack Morton and his henchman Roach, who are after a secret Confederate shipment. When Colecrest is badly injured, Artie must go for help while Jim holds off Roach and his men.. and deal with an elderly Confederate soldier.
Jim and Jeremy get a new partner, timid Bosley Cranston, during their investigation of an opium-smuggling ring led by businessman Gideon Stix. Cranston's photographic memory proves invaluable when they must break into Stix's house and duplicate the man's records.
Someone is selling "insurance" to rich businessman... and using a giant tuning fork to destroy their businesses with sound waves when they refuse to pay.
Dr. Loveless plans revenge on the people he holds a special grudge against, and kidnaps them one by one with a series of crimes based on a poem. Jim and his new partner Jeremy Pike go up against the good Doctor... and his steam-driven mechanical man.
West and Pike are on the trial of the villainous Chang and discover a plan to use Alcatraz Prison as the base of operations to take control of San Francisco.
Townspeople in New Mexico are under attack by bandits... who appear to be the ghosts of Cortez and his Conquistadores.
Dying crime lord Johnny Sabatini wants Jim to help his ward, the blind Sylvia, in exchange for him giving the agent information on another criminal, Boorman. Sylvia knows nothing about Sabatini's true background but has vague memories of the town of Calliope, MO. Jim and his new partner, chemist Ned Brown, investigate the matter and find that a $500,000 Army payroll was stolen and hid in Calliope, and someone knows more than they're telling.
Secret Service agent Fred Doorman is murdered after investigating reports of a traitor, and leaves behind a sheet of music as a clue. Jim and Jeremy try to decipher the possible code and Jim ends up at a Secret Service academy where a counterfeiting scheme is underway.
Jim and Artie get a message from an old friend that brings them to a fort at the Mexican border, where a group of men have infiltrated the outpost and plan to trigger a war with Mexico.
Jim meets with a newly-returned Artie in New Orleans, and Gordon has to accompany a temperamental Italian diva. Jim takes on Artie's duties but they're attacked at the opera and soon find that two other divas have disappeared within the opera house.
Jim travels to Bleak Island to collect a bequest to the National Museum, and teams up with former associate Sir Nigel Scott of Scotland Yard to defeat a master criminal named Calendar and his ghostly hound.
The royal family of Karovnia flees to the U.S. with a religious icon representing their family rulership. The person who forced them into exile and sent assassins after them, Count Balkovitch, needs the icon to assume power and only Jim and Artie stand in his way.
Governor Trent's daughter Averi is kidnapped by bandits, but while Jim goes to rescue her, Artie finds out that one of the men has the plague... and if Jim and anyone else exposed isn't treated in three days, they'll die.
Jim comes to the aid of the Jupiter Corporation, which has already lost two members. When acting chair Amelia Bronston vetoes a request for Jim to help, the agent teams up with the headstrong Lionel, son of one of the dead men.