Samantha Mulder's address, which was stated as 2790 Vine Street in her file, is actually the former address of The X-Files production office in Vancouver.
Shelly Owens, who played Tessa in this episode, is the sister of Chris Owens, who played the role of Special Agent Spender.
Scully: What makes this case anymore credible than the 100 year old mother with the lizard baby?
Mulder: Because the lizard baby wasn't born anywhere near Lake Okobogee.
Scully: Oko- what?
Mulder: Bogee. Okobogee.
Scully: Is that suppose to mean something to me?
Mulder: If you know anything about trout fishing or UFO hotspots.
Scully: Define hotspot.
The X-File that Blevins hands Scully pertaining to Samantha Mulder's abduction incorrectly spells the city's name as Chilmarc when it should be Chilmark.
Scully tells Blevins that Mulder's sister disappeared 21 years ago. However, Samantha Mulder disappeared on November 27th, 1973. At the time that this episode aired, October 21st, 1993, less than 20 years would have passed.