Andy tells a young pregnant woman whose had a heart attack, that in order for both her and her unborn child to be saved she'll need a heart transplant. However, the transplant is jeopardized due to unexpected complications with the donor's family.
An 18-year old in need of a double-lung transplant, struggles to survive as the team runs into an obstacle that may prevent her from being eligible for the procedure.
Andy battles UNOS (United Network for Organ Sharing) to allow a former drug addict to receive a new heart, but things become complicated when the patient disappears just before the surgery.
The parents of a football player killed in a bus crash must make a heartbreaking decision, whether to donate his organs or not. Meanwhile, Andy and Ryan scramble to find a procurement team so that a boy, desperately in need of a heart transplant can do so.
The partner of Andy's wife is suffering from an aortic aneurysm, causing Andy to attempt a new and risky procedure in order to save his life.
Lisa becomes very attached to an 8-year-old boy who she witnesses being crushed by a ride at a fair. Meanwhile, Andy and David try to get a VAD (ventricular assist device) for one of their patients.
When a dying man requests to be taken off of life support so his organs can be donated to save others, Andy doesn't know exactly what to do. Meanwhile, David tends to a foster parent who's got pulmonary hypertension and refuses admission to he hospital.
A billionaire is forced to buy a new liver for his wife after a setback leaves her, while one of Andy's former friends resurfaces.
When a bride is gunned down at her wedding, the team is sent to harvest her lungs to transplant into a college basketball player.
While Andy is forced to make the decision of whether he will allow a woman to begin a "daisy chain" and donate her kidney to a patient until an exact match is found for her husband, Andy has his suspicions that one of the recent patients are rejecting the new heart.
A firefighter has to deal with the hard choice of whether or not to be a living donor to her captain (who has mistreated her), while Andy's uncle shows up with a stab wound and requests him not to report the incident due to the fear it will violate his parole.