When an emergency occurs, the San Francisco City Hospital trauma team is the first on the scene no matter where the victims are. Flight medic Reuben "Rabbit" Palchuk, paramedics Cameron Boone and Nancy Carnahan, rookie pilot Marisa Benez, EMTs Tyler Briggs and Glenn Morris, and mentor Dr. Joe Saviano must fly into action when tragedy strikes close to home.
The team is sent to the scene of a major accident in which a car lost control and crashed through a street fair. Meanwhile, Nancy gets a new partner and Rabbit teaches Marisa a valuable lesson.
Boone's relationship problems are forced to be put on hold when a gunman goes on a rampage inside an office complex. The shooting causes Rabbit and Nancy to have to work together for the first time in over a year. Meanwhile, Marisa realizes how similar she is to Rabbit.
Tyler and Boone are called following an explosion at a Chinese restaurant. Meanwhile, Nancy's training is put to the test, and Rabbit reacts to a bumpy flight.
Chaos reigns at a Halloween party; Glenn and Nancy's shift takes a bizarre twist; and a partnership may change after a secret becomes exposed.
The tables are turned as Nancy and Glenn find themselves on opposing sides of a trauma. Elsewhere, the on-scene priorities of Boone are questioned, and Rabbit has a surprising reaction while treating a patient.
A boat crash causes mass mayhem, and San Francisco's finest must rush into action.
During Thanksgiving, a full commercial airliner is forced to make an emergency landing but it goes horribly wrong. Meanwhile, Nancy reluctantly spends the holiday with her family; and Boone and Tyler respond to a common Thanksgiving mishap.
When a bad batch of heroin is being dealt on the streets of San Francisco, Glenn questions Nancy's response to a "frequent flier." Meanwhile, Marisa sets out to track down a bizarre theft; Boone takes a new step that will affect his future; and a new romance blossoms.
Nancy must face one of her greatest phobias while treating a construction worker trapped underground after falling down a manhole. Meanwhile, Rabbit and Marisa are on the scene of a bank robbery to treat the injured. Elsewhere, Boone has a new position and his first decision may jeopardize the career of one of his own.
Glenn handles a procedure by the book and loses a patient, bringing the whole station under a "probie curse." Meanwhile, Rabbit's suspension leads him to mandatory therapy sessions to regain his wings as his relationship with Nancy intensifies. Elsewhere, Marisa deals with a new partner, while Boone and Tyler have a patient jump out of the rig.
Rabbit has a breakthrough in therapy that reveals a traumatic event from his past. Meanwhile, Nancy and Dianas difference of opinion puts a patients life at risk. Elsewhere, Tyler and Boone consider their futures, as Glenn reaches a career milestone.
Glenn and Nancy are caught in the crossfire when San Francisco is taken hostage by a sniper; Boone tries to get used to Tyler's new paramedic status.
Nancy ignores protocol while treating a high-school cheerleader; Rabbit and Marisa are quarantined after being exposed to a patient with meningitis; a misunderstanding tests Boone's partnership with Tyler.
Nancy and her father clash over his new role as head of the trauma center.
Glenn discusses unusual calls with his colleagues; Tyler's dad visits.
A problem with dispatch creates chaos when medics are sent scrambling to the wrong locations. Marisa reconnects with her army buddy Casey but their visit takes a dark turn. Boone plans a surprise party for Tyler's birthday. Elsewhere, Nancy,, who has a lot on her plate as she deals with a terminal cancer patient, ponders the next step with Rabbit in their relationship.