John Lowry and Stanley Friedman are an odd pair to be buddies. They’re polar opposites in every way and have a hard time seeing eye to eye. The one thing they can agree on is that they only have twenty good years left to live. In their moment of enlightenment, both men vow to live each day as if it is their last, despite what anyone thinks. It’s age meets anarchy and there will be no regrets.
When Jeffrey's controlling ex-girlfriend Gina, comes back into the picture, it doesn't sit well with John, who is afraid that his best friend's rekindled romance will foil all the adventures he has planned for the two of them.