Betty finds that everything is different as she starts her new job as associate features editor. Matters are made worse when she finds that her boss and ex-boyfriend, Matt Hartley, is still upset over their breakup. Meanwhile, without Betty, Daniel begins to spiral downhill and continues mourning the loss of his wife; Justin starts high school, but hides the fact that bullies are taunting him; and Wilhelmina continues to harbor a deep secret.
Betty gets the opportunity to run a Mode photo shoot, which is for the United Nation's anti-malaria campaign, "Nothing but Nets." Meanwhile, Amanda bonds with Daniel's temp, Helen, and Wilhelmina does everything possible to protect a loved one.
Marc is appointed as Betty's temporary assistant by Wilhelmina. Betty decides to do a story on the worst jobs in New York. Meanwhile, Hilda causes trouble for Archie's campaign and Daniel hires himself a beautiful but inept assistant.
Ignacio puts together a "multi-culti" holiday dinner for Jean, who is Jewish, while Betty and Hilda both have pregnancy scares. Both Betty and Hilda decide to buy Be-Shure instant pregnancy tests from a pharmacy where Jean and Ignacio happen to be shopping. Meanwhile, Hartley finds a replacement for Wilhelmina -- Denise Ludwig, a clueless mogul from Hollywood -- but Marc puts together a plan to get Wilhelmina back in control.
Worried she's spending too much time with Matt, Betty tries to find something else for Matt to be involved in, which turns out to be a gallery showing of his art work. However, the exhibit creates some unexpected results. Meanwhile, Marc learns his one-night stand is falling for him; Hilda debates telling Bobby that he's the father of her child; and Hartley hires a replacement for Wilhelmina.
As flashbacks tell the story of the last few days, Betty talks to Mr. Z about her worst week ever. However, when Wilhelmina has Betty work on various experiments, the new tasks nearly kill her. Meanwhile, Daniel learns that Marc is trying to sabotage him, and Wilhelmina makes a commitment to Connor.
Betty's building is robbed right before the karaoke party, and Betty is partly to blame for the break-in. Meanwhile, Amanda tricks Daniel and Wilhelmina into getting counseling; and Ignacio refuses to accept that Bobby is now part of Hilda's life.
Wilhelmina is furious when she learns about Wilhediva Hater, her drag queen impersonator. Meanwhile, Betty's blog wins her an award, which creates tension between her and Daniel; Amanda rehires Helen, but Wilhelmina later orders Amanda to fire her; and Marc runs his own photo shoot.
Wilhemina marginalizes Betty at Fashion Week, but Daniel has her reassigned to cover a low-priority show. There, Betty meets Marisa, one of the "10 Designers to Watch." Meanwhile, Amanda teams up with Helen to start a new line, but both Marc and Betty refuse to show their work to Wilhelmina.
To speed along the investigation into her house fire, Betty is pressured to date an annoying fireman, Jimmy. Wilhemina tries to prove to Don, an old flame from her past, that she's just "Wanda from the block" instead of an uber-bitch, and Amanda draws closer to Tyler, convincing Claire to hire him as an in-house model at Mode. Meanwhile, Hilda meets Bobby's parents for the first time.
Justin loves his acting class, helmed by the eccentric Lena Korvinka, and finds himself in an unexpected triangle with his new pals, Austin and Lily. When Betty drops by class, she's smitten with a cool young playwright, Zachary, whom she will profile for Mode. But she challenges her own ethics when she starts dating him. And Wilhemina is hospitalized with a perforated ulcer, and can't help her type-A personality even when bedridden, but then her roommate, Roberta, prompts an epiphany.
After being knocked unconscious at a photo shoot, Betty has a dream in which her orthodontist shows her how her life would have been had she never worn braces.
Amanda and Hilda join Betty on a trip to Fashion Week in London, where Betty reconnects with Christina (Ashley Jensen) and has a chance encounter with Gio (Freddy Rodriguez). Meanwhile, Wilhelmina goes to extremes to undermine Claire and Daniel by getting close to Tyler, and Bobby wonders why Justin and a classmate have become inseparable.
Betty asks Daniel to go to Hilda's wedding with her; Amanda wants to fix Marc up with her new client; Betty considers unexpected offers; Wilhemina uses Tyler as a pawn to fight the Meade empire.