Season One
Weeds is about a single mother named Nancy who sells drugs for a living. After the death of her husband Judah she had no source of income and decided that was it. To make sure she can continue to do this she buys a shop, which sells "cakes" so her real business is no longer under threat. This idea was brought to Nancy's attention from her pot smoking accountant, Doug. Nancy has two kids, Silas and Shane. Their uncle Andy also lives with them to help support them, although he does a poor job. At the end of the season Nancy meets Peter and after spending the night with him finds out he works for the DEA.

Season Two
Nancy Botwin secretly married Peter who happens to be a DEA Agent. She married Peter as a safety net, when the family found out they were angry with her because it was a dishonor to Judah and they did not like the guy. When things turned out bad and they broke up Nancy had to give Peter some money. Heylia and Conrad have a gang of Armenians kill Peter for a price. Nancy and Conrad were about to score a deal with a man named U-Turn and with that money pay the Armenians. However U-Turn put the guns on Nancy and Conrad to take their money. As Nancy went to get the pot it was gun as Silas had stolen it.

Season Three
In the 3rd season, Nancy has Silas selling for her now and U-turn is on her ass 24-7. After the death of U-turn, Nancy was able to work for herself again. She quit her job as Sullivans assistant who she's been sleeping with behind Celias back. When Celia finds out she threatens to shut Nancy down unless she lets her in. Nancy also seeked out protection as her business was being threatened by a biker gang. This lead to the town in flames causing everyone to evacuate and the grow house to be discovered. The grow house being under Sullivan's name claims he knew nothing about it, and it was all Celia who then blamed Nancy while her and the family left Majestic.

Season Four
What's Nancy Packs up and move on. With the embers of Agrestic smoldering in her rearview mirror, Nancy & Co. relocate to the fictional beach town of Ren Mar on the San Diego/Mexico border to set up shop with a new front biz that’s… pregnant with possibilities. With the help of her old friends and new partner Guillermo, Nancy will get even deeper in the shadier side of dealing — on both sides of the border. She's savvy and has earned her stripes in the business, but the new, un-chartered terrain ramps up the risk with every transaction. While there's a whole new look, new locale, new friends and even a new love interest, the patented Weeds dark humor that the country and critics have grown to love over the past three seasons stays true to form.