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Brian considers ending another dead-end relationship with his latest girlfriend. He makes a pact with Adam, his best friend since childhood, that they both break up with their respective girlfriends. But after Brian breaks up with his latest love, Adam chickens out and instead proposes to his girlfriend, Marjorie, whom Brian actually considers his own Miss Right -- a secret that he must keep to himself. Meanwhile Dave, who runs a video game business with Brian called Zap Monkey, and his stay-at-home wife of 13 years, Deena, discuss a possible venture into the world of open marriage. Brian’s fortysomething sister, Nic, and her younger husband, Angelo, are trying hard to start a family, but something’s not right and their efforts to get pregnant experience a setback. Despite all of the challenges these couples face, they can’t wait for Brian to join their “club,” though they’re not exactly sure why.

Episode Info
Episode number: 1x1
Production Number: 101
Airdate: Sunday April 16th, 2006

Director: Dan Lerner
Writer: Dana Stevens

Alternate Airdates:

Finland Jan 11, 2007
UK (E4) May 01, 2007
NL (Net 5) Aug 30, 2009

Guest Stars
Amy Jo JohnsonAmy Jo Johnson
As Karen (car girl)
Daniel BessDaniel Bess
As Steve
Jud TylorJud Tylor
As Lisa
Mikaila BaumelMikaila Baumel
As Larissa
Payton SpencerPayton Spencer
As Geneva
Courtney MunCourtney Mun
As babysitter
Emily LiuEmily Liu
As passing woman doctor
Greg GrunbergGreg Grunberg
As Samaritan driver
Nelson MashitaNelson Mashita
As mattress salesman
Episode Notes
Brian: Video Game Business: Zap Monkey
Dave: Video Game Business: Zap Monkey
Deena: Stay-at-Home Mom (3 Daughters - one is a new baby)
Adam: Lawyer
Marjorie: Pediatric Surgeon
Nicole: Record Executive
Angelo: Actor

Episode starts at 10:01 PM (EST).
A 59 minute episode.

It was originally scheduled to premiere Sunday, April 2 and move to its regular Monday home the next night. However, "The Ten Commandments" has moved the debut of "What About Brian" to Sunday, April 16

Episode is to air at a special time in Grey's Anatomy time slot on Sunday.

ArtistSong TitlePlayed When
Air SupplyAll Out of Love 
Simon & GarfunkelLate In the Evening 
Snow PatrolChocolate 
Tom PettyAmerican Girl 
U2Stuck in a Moment You Can't Get Out Of 
The WhoBaba O'Riley 

Episode Quotes
Karen: (to Brian) I'm going to get a restraining order.

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