Ryan betrays Wilfred's trust to gain favor with Jenna and finds an unexpected secret about her.
When Ryan FEARS his neighbor Spencer has been paying special attention to him lately, Wilfred, amidst talk of confrontation and dominance, confesses that he left Ryan’s wallet at Spencer’s house the night they broke into it. Ryan avoids a conflict when Spencer confronts him with the wallet, causing Spencer to want to hang out with Ryan, much to his dismay. Later, when a prank on Wilfred with a laser pointer causes the dog to attack their Indian neighbor, Ryan tries to bribe the animal control officer taking him to cut him loose, but he turns out to be Spencer’s ex-best friend, Jesse. Wilfred is taken to be put down, and Ryan takes Spencer to the pound, leaving him to talk to Jesse. After Ryan gets the two men to mend fences, Jesse gives Wilfred back. Thinking its over, Ryan returns home, only to find Jesse and Spencer in his house making plans for the three of them. Ryan snaps and confesses to everything to Spencer, causing him to assault Ryan. Wilfred hits Spencer with a bone, knocking him unconscious, and Ryan, coached by Wilfred, gets Jesse to take Spencer out of Ryan’s house, never to return.
Ryan tries to reconcile with his sister (Dorian Brown), and Wilfred is in for a shock at doggy day care as a result.
Ryan volunteers at a hospice, but it's Wilfred who turns out to have a talent that's much in demand there. This gives him the leverage to make demands of his own.
Against his better judgment, Ryan agrees to help Wilfred get rid of Jenna's alpha-male boyfriend.
Wilfred’s pursuit of a new love interest forces Ryan to swallow his pride – among other things.
Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss (Nestor Carbonell).
Ryan's nutty mother (Mary Steenburgen) moves in with him after spending 20 years in a "wellness center" and bonds with Wilfred instantly, adding fuel to Ryan's already-considerable resentment of her.
Wilfred is troubled by Ryan's tendency to keep to himself ("People are beginning to think you're weird," he tells him), so he sets out to make his human friend more sociable. Of course, Wilfred also has an ulterior motive.
Ryan begins to suspect that his friendship with Wilfred might not be in his best interests. Then he meets a guy (Dwight Yoakam) who confirms the suspicion.
An attractive Italian woman (Gabriella Pession) is attracted to Ryan, but his responsibilities (waiting for Jenna's cable guy; unclogging Kristen's drain) keep intruding. Wilfred also intrudes, to say the least. Meanwhile, Jenna gets a promotion at work.
Ryan and Wilfred face an existential crisis after the former ignores the latter's advice.
Ryan learns that life is much more challenging without Wilfred around.
Wilfred accuses Ryan of being selfish and refuses to help him with his problems.
Problems emerge for Ryan as result of Wilfred's popularity.
Wilfred becomes embattled with an unlikely foe, forcing Ryan to intervene.
Unforeseen problems arise for Ryan and Wilfred after a traumatic occurrence.
Wilfred muddles Ryan's plan to introduce Amanda to Jenna.
A hairy situation puts Wilfred and Ryan's friendship in jeopardy.
Wilfred's nemesis returns with an offer that rocks Ryan's world.
A spontaneous road trip proves disastrous for Wilfred and Ryan.
Ryan and Wilfred make an extraordinary effort to boost Jenna's career.
Ryan attempts to discover the truth about Wilfred through self-examination.
Wilfred sabotages Jenna and Drew's wedding on account of Ryan's jealousy.
In the second-season finale, existential questions are posed to Wilfred and Ryan.
Ryan and Wilfred search for Wilfred’s original owner. Written by Reed Agnew & Eli Jorné; directed by Randall Einhorn.
Ryan befriends Wilfred’s enemy—the mailman. Written by Cody Heller & Brett Konner; directed by Randall Einhorn.