Looking forward to starting her sophomore year without living in the dorms and not being nowhere near her “crazy lady” mother, Amy is in for a surprise when her dorm room isn’t what she expected. As a result, she starts looking for a new place to move into, ultimately passing up rushing a sorority to share a house with four guys.
After living with the guys for a while, Amy decides that it’s time to set some house rules when she gets tired of cleaning up after them. However, it doesn’t take long for the guys to get tired of the rules and they soon come up with a plan to trick Amy into going along with the house rules that were in place before she moved in.
Amy enjoys her new job at the bookstore until her boss becomes too friendly.
When Alpha’s sorority house has a flood, Stacy goes to stay with Amy and the guys for the night before Jason is able to fix the plumbing. However, it doesn’t take long for Stacy to get on Amy’s nerves during her stay that she orders the guys to clean up the sorority house while Stacy tries to plant her hooks in Jason.
Amy turns to a her roommates for support after learning that her new boyfriend is "fizzling" her.
Amy’s in for a surprise when her extremely overprotective mother shows up for a visit. Meanwhile, the guys' camping trip is cut short by bad weather.
The night before the campus chili cook-off, Amy has a steamy dream about Jason that makes her confront her feelings for her roommate.
When the guys embarrass Amy after declaring an impromptu prank war on her, she decides to take a page out of their book and pull the ultimate prank on them as payback.
After getting a failing grade in one of her classes, Amy starts to doubt whether she wants to pursue her dream job in Marine Biology. Meanwhile, Dude wonders where he is going to be able to find a job now that his parents decided to stop paying his way through school.
With their mid-terms rapidly approaching, Amy takes the guys to the library to study. However it doesn’t take long when they arrive there to discover that the cute co-eds are more important to study than their upcoming tests.
After a routine traffic stop results in the police officer putting a boot on Amy’s car, she gets in an argument with Dude and McRitchie over who should pay the fine. Meanwhile, Benny invests in Erin’s new business in order to spend some time with her.
While the gang goes on a camping trip, they get an extra guest when Erin decides to come along for the weekend. In an attempt to spend some time with Jason, Amy sets Erin up with Dude and is less than thrilled with the results with the match-up. As a result, their arguing gets in the way of Amy’s attempt of starting a relationship with Jason. Meanwhile, McRitchie and Benny make some new friends in the woods.
When the guys’ old roommate Stan returns to town with his band, Amy starts to worry that he might decide to stay and want his room back. When her fears are realized, she goes to work to get Stan to live up to his nickname and try to reconcile with the other members of his band. Meanwhile, Benny goes to work with Dude in locating his father, who slipped into town for a reunion.