Babes focused on sisters Charlene, Darlene, and Marlene Gilbert, who lived in a huge studio apartment in Manhattan. Darlene, who was the oldest, was divorced and worked as a dog groomer. Charlene, the middle sister, was a makeup artist for a photographer. While the youngest, Marlene, had no job at all and was at a loss about what she wanted to become.
The show set itself apart from other shows at the time in that all the three sisters were overweight and were played by overweight actresses.