Based on a popular comic strip created by Jerry Scott and Rick Kirkman, Baby Blues centers around Darryl and Wanda MacPherson and their child Zoe.
Darryl (Mike O'Malley) and Wanda (Julia Sweeny) are new parents who are trying to survive through the obstacles of parenthood. They also have to face dealing with their next door neighbors Carl (Joel Murry ), Melinda (Arabella Field), and their three kids Rodney, Meagan (both voiced by Kath Soucie), and Shelby Bitterman.
Darryl's best friend and co-worker Kenny (Deidrich Bader) is the one that Darryl goes to for advice. To help them, Daryl and Wanda hire Bizzy (Nicole Sullivan); a hip teen to babysit Zoe. The show presents the toughness of being new parents by showing the day to day problems of Wanda and Darryl.