Famed gambler Bret Maverick arrives in the Arizona Territory town of Sweetwater for a big poker tournament and ends up cleaning house, winning a saloon called the Red Ox and a large bundle of cash. Bret decides that Sweetwater would make a nice place for him to settle down so he uses the cash to purchase a ranch called the Lazy Ace. However, when robbers steal his money, Bret has to ride off after them with a lame-duck sheriff, a female reporter, and a scheming Indian scout as his only help.
The only thing stopping the railroad from coming to Sweetwater is that part of it is slated to go through Bret Maverick's ranch, the Lazy Ace, and he doesn't want to sell.
Bret unwittingly wins a Chinese girl in a poker game and can't seem to find a way to get rid of her. Meanwhile, the suffrage movement comes to Sweetwater and Kate and Mary Lou team up to take on Elijah and win the vote... despite the fact that only men can participate in the referendum.
Congressman Theodore Roosevelt arrives in Sweetwater to present the gift of a white stallion to Apache chief Geronimo. However, unknown to Roosevelt, the horse has been stolen and Bret later won it in a poker game. Meanwhile, an attractive businesswoman sets her sites on Tom.
A Tucson land combine begins purchasing Sweetwater businesses using Chicago gangster methods so the townspeople turn to Bret in desperation to find a way to outwit the land thieves.
An old flame of Bret's arrives in Sweetwater but she's on the run from two homicidal brothers whom she earlier swindled.
A drifter arrives in Sweetwater and he's out to finish a song he's writing about the life and death of Bret Maverick. Meanwhile, Bret tries to unload a silver mine he won in a poker game but every potential buyer thinks it's a scam.
Tom Guthrie's past catches up to him when a woman and her hired guns break into the Red Ox and put him on trial for two murders that he supposedly committed during the days before he became a lawman. Bret is captured and is forced to play for time by acting as his partner's defense attorney.
Six gunmen accompany a pulp writer to Sweetwater in hopes of winning fame by being the one to kill Bret Maverick.
The citizens of Sweetwater call in the cavalry after a stagecoach is robbed and a female passenger is killed by Apaches. However, Philo Sandeen insists that the crime was committed by white men.
A charlatan who heads a phony religious sect uses legal means to swindle the people of Sweetwater out of their land.
After being swindled out of their land by a religious charlatan, the people of Sweetwater look to Bret Maverick in order to turn the tables.
Bret Maverick and Tom Guthrie get snookered into protecting a gold shipment from a band of ruthless outlaws.
Tom Guthrie is running for re-election as sheriff and wants business partner Bret Maverick to keep a low profile in the campaign. However, Bret is working on one of the biggest scams of his life and isn't about to be kept under wraps.