A new nurse called Barbara, who is anxious to prove herself gets off to a bad start. A family of neglected children is discovered and Trixie becomes determined to restore their health and bring happiness into their lives.
Barbara has to deal with her most challenging case yet after she helps a first-time mother as the birth does not to go according to plan. A new nurse shows up and soon makes an impression on Sister Evangelina.
After Poplar has a mysterious outbreak of dysentery, first-time mother Marie Amos's life ends up being turned upside down after her husband Tony is arrested for gross indecency with another man. Patsy attempts to help the young couple, as Tony faces a criminal hearing. Nurse Crane attempts to help a pregnant Irish woman with two young children are covered in flea bites and clearly malnourished.
Sister Winifred learns about Poplar’s seedy underworld after she looks after Bridget Cole, an expectant prostitute. Shocked by the girl’s lack of awareness, she has to use her past teaching experience and help from SGT Noakes in an effort to promote 'safe sex' to the local working girls. Barbara finds it hard to understand why expectant father, Frank Robbins, is so desperate to have a son.
Sister Julienne is forced to question absolute faith after she meets a Christian Scientist couple who refuse medicine for their new-born child. Things become more difficult after the parents are accused of harming their child.
A secret romance ends in heartbreak after teenager Paulette Roland learns that she is pregnant. Nurse Crane helps support the couple but Paulette's life is endangered after the two youngsters go on the run.
A water shortage leaves Maternity Home is busier than ever. Two former school friends called Shirley and Marion are reunited and they are both pregnant with their first child but are now worlds apart.
Trixie and Sister Mary Cynthia work together to support a deaf mother to be, while a case of morning sickness ends up being more serious than at first suspected. Fred’s daughter is not happy about his upcoming wedding.