The series follows twenty-something April (Ricci), a smart and quick witted aspiring journalist who is trying to work her way up the ladder at a Boston newspaper by trying to impress her hard-nosed editor. When not pursuing the latest scoop, April tries to balance her ambitious career with her family – her widowed mom Sara (Keller), rebellious little sister Brenna (Ramm) and her grandmother. Just as things start to look up at work, home and on the romance front with co-worker Dominic (Brancatisano), April gets the devastating news from an estranged uncle that she has cancer.
As the wedding date draws near, April is forced to face a list of “lasts,” such as her last week of living at home and her last time being a single girl. While her natural instincts are to have a classy and low-key bachelorette party, Vanessa (Krysta Rodriguez) helps April realize that this might be her last time to live it up. Another possible “last” opportunity presents itself for April when Dominic sets up a meeting for April with his book agent. With her health still in question, this opportunity may be April’s first (and last) chance to get a book published.
Meanwhile, Leo tries to play nice with Dominic and Brenna reaches out to Finn.
An unpublished novel written by April's father could hold clues about her family's past. April decides to use it to do some investigating.