After winning the war for the Allies, Danger 5 have since disbanded, however when Colonel Chestbridge, their wartime leader, is brutally murdered in a London shopping mall and attempts are made on each of their lives, Danger 5 re-unite to mix up a fresh cocktail of revenge, intrigue and bullets.
Hitler has infiltrated a high school in search of a female senior student. Danger 5 are forced to go undercover and back to school, where Tucker's teaching skills are pushed to the limit, Pierre's coolness is put to the test and Jackson is hunted by a ruby-eyed wolf man with a machine gun and a grudge.
Danger 5 are fugitives in Metro City, wrongfully accused of kidnapping high school senior Holly De Palma. Hitler has infiltrated the police and leads the hunt for Danger 5 but little does he know that his own people are working against him: Joseph Mengele and his sinister accomplice Mr. Pedro are plotting a scheme, which involves the return of some scaly prehistoric bad-guys.
After being abducted by Mr. Pedro, Hitler is taken captive in the Vatican. A gang of surviving Nazi war criminals have formed a mutiny against Hitler and plan to hijack Catholicism in a bid for world domination. Pierre's faith is put to the test as he fights to save Christmas from the Nazis. Meanwhile Tucker retreats into a fantasy world, Ilsa encounters an old flame and McKenzie investigates Holly's newfound ability.
Hitler returns from Hell as a zombie, and chases Holly into USSR Land in an attempt to find the perfect indestructible body. Meanwhile, Ilsa has a family reunion while hunting down Khrushchev, Jackson tries to fight his way out of the friend zone, and Tucker begins to accept that Claire's severed head might be dead.
Danger 5 go back to World War II in an attempt to stop Hitler from changing the fabric of time. Ignoring the perils of messing with the space-time continuum, Tucker is dead set on changing the course of history for his own selfish motives while Pierre suffers the consequences. Jackson and Ilsa have a run-in with their past selves and share advice on the future. Meanwhile Hitler is holding Colonel Chestbridge hostage in his mountain lair.
In the final instalment of Danger 5, the team find themselves in an alternate future where Hitler is undisputed ruler of the universe. In Hitlerland everyone speaks German, everyone loves dogs and worst of all, everything is vegetarian! Danger 5 embark on a quest across space dodging Hitler's deception at every turn. They encounter old friends, new foes and a talking pelican on this epic quest to save the universe.