Brown's second live stage show, Something Wicked This Way Comes, toured around the UK following its success in the West End. The tour began in March 2005 at the Cambridge Theatre and finished in May at the Hammersmith Apollo. The run was then once more extended into the following year, being performed and filmed for a final time at the Old Vic Theatre in mid-June 2006.
A 90-minute edit of this show was broadcast on 29 December 2006, 10 June 2007 and 17 June 2008 on Channel 4, on 10 May 2008, 17 Jan 2009 and 6 Jan 2012 on E4; a longer, unedited version was released on DVD in May 2008. The show won the Laurence Olivier Award for Best Entertainment Show 2006. The show was co-written and directed by his long time collaborator Andy Nyman. The title is a direct quote from William Shakespeare's Macbeth; Act 4, scene 1, line 45.