After being involved in an accident that resulted in her going blind, a young woman seeks Mark's help to find the criminals.
When Jim, the hospital janitor, becomes a victim of murder, Mark and Steve investigate his twin brother, Jeff.
Following the death of an unpopular reality show contestant that Alex was participating in, Mark decides to go undercover in the house to see guy actually died of an overdose or if one of the other contestants killed him.
A man is murdered at a retreat at a nearby Church, Fr. Dominic; the priest on duty is found standing over the body giving him last rites, and as a result is considered the prime suspect when Steve begins his investigation. In looking to prove the priest’s innocence, the parish monsignor calls in Mark to investigate and prove that Fr. Dominic was framed.
When three med students decide to play a risky game of flat-lining, one accidentally dies when his friend refuses to let his girlfriend revive him. When Alex asks Steve to investigate his disappearance when he fails to show up for classes, they get a surprise when Casey, a temporary pathologist finds the student in the lab with his blood drained. Realizing the student was murdered, Steve and Mark begin to investigate the two students who flat-lined with the deceased and eventually learn why his death occurred.
When a patient of Mark is assassinated during a check-up, the events following her death forces him to confront the events that followed his father's death.
Mark and Steve get introduced to the world of high-stakes poker when a cardiologist who is a compulsive gambler becomes the prime suspect in the murder of a disreputable bookie. When the doctor is later found dead in his apartment of an apparent suicide, they are certain that the doctor didn’t take his life and that one of the poker players the doctor played against had something to do with his death.
Dr Mark Sloan becomes entangled in a serious incident with the Chinese government when Amanda tries to hide a famous ballet dancer who plans to defect to the US.