Marvel are launching a new ten-page series in the rebranded "Amazing Spider-Man Family" in June 2008 called "Mr and Mrs Spider-Man". It's part of the MC2 universe, which Spider-Girl belongs to.
What's known so far is
1. The Lizard will be in the first issue
2. Peter's daughter is returned to him and MJ by Kaine
3. This takes place two years before Peter loses his leg in a final battle with the Green Goblin.
Thankfully, in MC2, Aunt May never came back from the dead either, and the marraige is still intact. So if anyone has a better excuse to ditch the mess that is Spider-Man presently, there you go.