You know, I think I'm kind of at peace with Scrubs going off the air. 6 seasons is a pretty good run and its already passed the 100 episode mark a while ago, so I wouldn't think of it so much as a cancelation but more as a retirement. Besides the ratings over at NBC are really really low so I don't see how it would be a logical move for them to pick it up. Whenever they pick up a low-rated show they use the "its off to a slow start, but it will become a hit" excuse. Like they did with Seinfeld, and The Office and are currently doing with 30 Rock. But that wouldn't really work with Scrubs since if it returns, it would be in it's 7th season.
However, I might die if Veronica Mars, Supernatural or How I Met Your Mother go away after only having been on 2 or 3 years.