The lives of Dick and Paula Hollister, a New York couple. Dick Hollister (Richard Benjamin) was a cartoonist whose creation "Jetman" had just been made into a TV series. Paula Hollister (Paula Prentiss) was his rather ditzy but well-meaning wife who was employed as a social worker. The storylines frequently revolved around Dick and Paula's relationship with Oscar North (Jack Cassidy), an egotistical actor who played Dick's cartoon creation on the TV screen. Despite solid critical reviews for the performances of Benjamin, Prentiss, and Cassidy, He & She never caught on in the ratings and was cancelled after only one season on the air by CBS.