All five members of the Girardi family are named after saints.
The series is set in the fictional town of Arcadia in Maryland.
In the original draft of the pilot, the Girardi family were named the Delaneys.
Kevin: Ever get the strange feeling you're being discussed?
Luke: I never get that.
Kevin: Because you're too boring.
Sammy: You don't happen to have any references on you.
Joan: No, but I was sent by God...
(He looks at her like she's crazy)
Joan: She said! Revealing her acerbic wit!
Joan: So you're a science geek, right?
Luke: I prefer "man of science."
Will: Helen, Canada's where people go when they can't really afford to go on a vacation.
God: I'm omniscient, Joan - it comes with the job.
Joan: Let's see a miracle.
Cute Boy (God): How about that?
Joan: It's a tree.
Cute Boy (God): Let's see you make one.
Helen: Let's sit down to a normal family brekfast.
Luke: Yeah, let's try something new.
Will: Did you happen to see his shoes?
Joan: Oh, yeah. I think they were Gucci.
Sammy: (on the phone) Is it breathing? It's moving? It's hopping? If it's hopping it's not dead!
Luke: So, what you do is that you shoot these photons at this piece of paper--
Joan: And a pervert appears in the yard.
Luke: As the great physicist Faraday once said, "Nothing is too wonderful to be true."
Joan: What about my hair?
Luke: It's on your head.
Joan: Who are you?
Cute Boy (God): I've known you since before you were born, Joan.
Joan: I'm going to ask you one more time.
Cute Boy (God): I'm God.
Joan: You're what?
Cute Boy (God): God.
Joan: Don't ever...talk to me again.