Masters Of Sex stars Michael Sheen and Lizzy Caplan as the real-life pioneers of the science of human sexuality, William Masters and Virginia Johnson. The series chronicles the unusual lives, romance and pop culture trajectory of Masters and Johnson. Their research touched off the sexual revolution and took them from a mid-western teaching hospital in St. Louis to the cover of Time magazine and nearly a dozen appearances on Johnny Carson's couch. Masters Of Sex marks Sheen's first regular series role for television. The series is an adaptation of Thomas Maier's book Masters of Sex: The Life and Times of William Masters and Virginia Johnson, The Couple Who Taught America How To Love.