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Lee Kanker is most likely the eldest of the Kanker sisters, and also the meanest. She has a rather gravely voice and has lots of curly red hair that covers her eyes. Each Kanker girl is madly in love with one of the Eds. And for Lee, it's Eddy.

Sarah is a bossy spoiled little sister, who acts cute and charming only when it serves her. Sarah has Ed's unending loyalty and obedience, mostly from her threats of snitching on him. She has a short temper and is easily agitated by others, especially her brother. She is almost always playing with Jimmy, and when she's not, rushes to his aid the moment Jimmy calls her. Sarah writes about her innermost feelings in her diary, and has a slight love for Edd but it usually is not enough to spare him from her wrath.

Known as Kanna of the void. She's one of the incarnations of Naraku, and has a mirror that can suck out people souls and control them. She is very loyal to Naraku.