Danielle Panabaker was born Georgia, the oldest of two children. Her younger sister Kay Panabaker
is also an actress. She took a theater class at a summer camp where she first realized she loved acting, so she started acting in Community Theater at the age of ten, later auditioning for commercials. She moved to Naperville, IL where she went to Crone Middle School and later Neuqua Valley High School in Naperville and participated in the speech team. She graduated from the school when she was 14 years old. Later, Panabaker feeling it was the only way to get into acting regularly relocated to Los Angeles, California in order to pursue an acting career. In 2005 she earned her Associate's degree, and appears on the National Dean's List. In fall 2006 she will begin her senior year at UCLA.
Panabaker has a Yorkshire terrier named Peanut, and likes to shop, read and dancing. She lives in Los Angeles area with her family. She also recently got another Yorkshire terrier named Butter.