An inside look at the home of Bryan and Jenny Masche, first-time parents coping in raising sextuplets. Jenny is also in training as a marathon runner and is preparing to go back to work. Bryan, meanwhile, is trying to drop the "sympathy weight" he gained while Jenny was pregnant.
Disagreements ensue when the Masches make plans to redecorate their home, which will include the removal of a 30-foot high tree which Jenny wants to keep. Meanwhile, Jenny designs Halloween costumes for the kids.
Not every member of the family is happy that Jenny has opted to have plastic surgery to repair damage from a recent pregnancy. Elsewhere, Jenny receives help from her mother to prepare for Thanksgiving.
Christmas time finds the Maches choosing a tree, taking a family photo, and heading into Las Vegas for some shopping. Later, the kids ride the Polar Express where they see snow for the first time ever.
Jenny and Bryan discover their parenting styles clash, as they take the kids for a trip to California. Later, Jenny participates in a half-marathon.
Bryan and Jenny receive on the correct way to discipline toddlers. Elsewhere, the kids learn to swim, and then the family heads to a wildlife preserve.