| •Amanda Baker | played | Babe Carey #2 (2007-present) |
| •Rebecca Budig | played | Greenlee Smythe (1999-2005, 2008-) |
| •Bobbie Eakes | played | Krystal Carey Martin (2003-present) |
| •David Canary | played | Adam Chandler / Stuart Chandler (1983-present / 1984-present) |
| •Brianne Moncrief | played | Colby Chandler (2008-Present) |
| •Melissa Claire Egan | played | Annie McDermott Lavery (2006-present) |
| •Colin Egglesfield | played | Dr. Josh Madden (#2) (2005-present) |
| •James Mitchell (1) | played | Palmer Cortlandt (1979-present) |
| •Thorsten Kaye | played | Zach Slater (2004-present) |
| •Michael E. Knight (1) | played | Tad Martin (#3) / Ted Orsini (1982-1986, 1988-1990, 1992-present / 1993-1994) |
| •Susan Lucci | played | Erica Kane |
| •Ray MacDonnell | played | Dr. Joe Martin |
| •Cameron Mathison | played | Ryan Lavery (1998-2002, 2003-present) |
| •Alicia Minshew | played | Kendall Hart (#2) (2002-present) |
| •Ricky Paull Goldin | played | Dr. Joseph 'Jake' Martin Jr. #6 (2008-present) |
| •Yaya da Costa Johnson | played | Cassandra Foster (2008-present) |
| •Debbi Morgan | played | Angie Baxter Hubbard (1982-1990, 2008-present) |
| •Sydney Penny | played | Julia Santos Keefer (1993-1996, 1997; 2002; 2005-present) |
| •Leven Rambin | played | Lily Montgomery / Ava Benton (2004-present / 2007-present) |
| •Chrishell Stause | played | Amanda Dillon (#2) (2005-present) |
| •Sterling Sulieman | played | Dre Lerman (2007-present) |
| •Aiden Turner | played | Aidan Devane (2002-present) |
| •Brent Weber | played | Sean Montgomery (2006-present) |
| •Walt Willey | played | Jackson Montgomery (1987-present) |
| •Darnell Williams | played | Jesse Hubbard (1981-1988; 1994; 2001; 2008-present) |
| •Jacob Young (1) | played | JR Chandler (#3) (2003-present) |
| •Lee Meriwether | played | Ruth Parker Martin (1996-1998; now recurring) |
| •Alec Musser | played | Del Henry (#2) (2005-present) |
| •Tonya Pinkins | played | Livia Frye Cudahy (1991-1995; 2003; 2004-present) |
| •Billy Miller (4) | played | Richie Novak (2007-present) |
| •Eileen Herlie | played | Myrtle Fargate (1976-present) |
| •Ambyr Childers | played | Colby Chandler (2006-2008) |
| •Jeff Branson | played | Jonathan Lavery (2004-2007) |
| •Abby Wathen | played | Colby Marian Chandler (#3) (2002 / via Adam's visions) |
| •Abigail Spencer | played | Rebecca 'Becca' Tyree (1999-2001) |
| •Akili Prince | played | Terrence Frye (#1) (1991) |
| •Alan Dysert | played | Sean Cudahy (1980-1981; 1988-1991) |
| •Alana De La Garza (2) | played | Rosa Santos (2001) |
| •Albert Stratton | played | Eric Kane (1989) |
| •Alexa Havins | played | Babe Carey Chandler (2003-2007) |
| •Alexander Scourby | played | Nigel Fargate (#2) (1976-1977) |
| •Alexandra Daddario | played | Laurie Lewis (11/2002-06/2003; recurring otherwise) |
| •Alexis Manta | played | Amanda Dillon (#1) (1997-1999; recurring otherwise) |
| •Alice Haining | played | Liza Colby (#2) (1984) |
| •Alla Korot | played | Allison 'Allie' Doyle (1997-1998) |
| •Allison Hirschlag | played | Laura Cudahy (#1) (1984) |
| •Amanda Bearse | played | Amanda Cousins (1982-1984) |
| •Amanda Seyfried | played | Joni Stafford (11/20/02-08/14/03) |
| •Amber Barretto | played | Emily Ann Sago Martin (#3) (1986-1988) |
| •Amelia Heinle | played | Mia Saunders (2001-2004) |
| •Amelia Marshall | played | Belinda Keefer (#2) (1996-1999) |
| •Amir Williams | played | Jamal Wilson Cudahy (#2) (1993-1995) |
| •Andrew Jackson (1) | played | Dr. Stephen Hamill (1991-1992) |
| •Ann Flood | played | Bitsy Davidson (#2) (1988 - 1989) |
| •Ann McDonough | played | Esther Glynn (1997; 2000) |
| •Antoinette Byron (2) | played | Antoinette 'Skye' Patterson Chandler (#1) (1986-1987) |
| •Antonio Fargas | played | Les Baxter (1982-1983; 1987) |
| •Ara Celi | played | Raquel Dion Santos (#2) (1999) |
| •Avis McCarther | played | Nancy Grant Fisher (#2) (1975) |
| •Barbara Kearns | played | Nina Cortlandt Warner (#3) (1985-1986) |
| •Bobby Steggert | played | Samuel Carlos Grey (2005) |
| •Brent Barrett | played | Tony Barclay (1983-1984) |
| •Brian Gaskill | played | Bobby Warner (#1) (1995-1997) |
| •Brian L. Green (1) | played | Brian Bodine (#3) (1993-1994) |
| •Brian Lima | played | Charlie Brent (#2) (1976-1980) |
| •Brianne Mullan | played | Colby Marian Chandler (#1) (2000 / Alternating Role) |
| •Cady McClain | played | Dixie Cooney Martin (#2) (1989-1996, 1998-2002) |
| •Candice Earley | played | Donna Beck Tyler (#2) (1976-1992; 1993; 1995) |
| •Carmen Thomas | played | Hillary Wilson Martin (1984-1988) |
| •Carol McCluer | played | Melanie Sawyer (1982) |
| •Carolyn Neff | played | Raquel Dion Santos (#1) (1998-1999) |
| •Carrie Genzel | played | Antoinette 'Skye' Patterson Chandler (#3) (1996-1997) |
| •Catherine Christianson | played | Dr. Amy Stone (1986) |
| •Charles Frank | played | Dr. Jeff Martin (#2; #6) (1970-1975, 1988, 1995) |
| •Charles Keating | played | Dr. Damon Lazarre (1987) |
| •Charles Van Eman | played | Charlie Brent (#5) (1990-1991) |
| •Chris Bruno | played | Michael Delaney (1995-1997) |
| •Chris Hubbell | played | Dr. Charles 'Chuck' Tyler III (#3) (1973-1975) |
| •Christian Campbell (2) | played | Bobby Warner (#2) (2004-2005) |
| •Christine Thomas | played | Kate Martin (#2) (1970) |
| •Christopher Holder | played | Wade Mathews (1986) |
| •Christopher Lawford | played | Charlie Brent (#6) (1992-1996) |
| •Christopher Wines | played | Dr. Jeff Martin (#1) (1970) |
| •Claire Beckman | played | Silver Kane (#2) (1988) |
| •Connie Fletcher | played | Erin Lavery (2005-present) |
| •Cornelius Smith Jr. | played | Frankie Hubbard |
| •Courtney Gibbs | played | Galen Henderson (#1) (1992) |
| •Dack Rambo | played | Steve Jacobi (1982-1983) |
| •Daniel Cosgrove | played | Scott Chandler (#3) (1996-1998) |
| •Daniel Hugh Kelly (1) | played | Travis Montgomery (#2) (1993-1994) |
| •Daren Kelly (1) | played | Dan Kennicott (1976-1979) |
| •Darlene Dahl | played | Anita Santos (#3) (1995-1997) |
| •David Beecroft | played | Josh Waleski (later Elliot Freeman) (#2) (2000-2001) |
| •David Forsythe (3) | played | Jim Thomasen (#2) (1997-1998) / Bob Thomasen (1998) |
| •David Jordan | played | Trevor Dillon (#1) (1989) |
| •David Kissell | played | Chris Morgan (1984-1985) |
| •Dawn Marie Boyle | played | Dottie Thornton Martin (#1) (1977-1980) |
| •Dean Tarrolly | played | Trask Bodine (#2) (1990-1991) |
| •Deborah Goodrich | played | Connie Wilkes (1982-1983) |
| •Diana DeVegh | played | Ann Tyler Martin (#1) (1970) |
| •Don Blakely | played | Dr. Frank Grant (#1) (1972) |
| •Don Scardino | played | Greg Nelson (#2) (1984) |
| •Dondre T. Whitfield | played | Terrence Frye (#2) (1991-1994) |
| •Donna Pescow | played | Dr. Lynn Carson (1983) |
| •Dorothy Lyman | played | Opal Gardner Cortlandt (#1) (1981-1983) |
| •Dylan Fergus | played | Tim Dillon (#2) (2002) |
| •Eddie Earl Hatch | played | John Remington (1988-1989) |
| •Eden Riegel | played | Bianca Montgomery (2000-2005, recurring otherwise) |
| •Eileen Letchworth | played | Margo Flax Martin (1972-1976) |
| •Elissa Leeds | played | Brooke English (#1) (1971) |
| •Elizabeth Hendrickson | played | Mary Frances 'Frankie' Stone / Maggie Stone (2001 / 2002-2005; recurring otherwise) |
| •Elizabeth Lawrence (1) | played | Myra Murdoch Sloane (1979-1991) |
| •Ellen Wheeler | played | Cindy Parker Chandler (1987-1989; 2000; 2001) / Karen Parker (1989-1990) |
| •Eric Dearborn | played | Gabriel Devane (2001) |
| •Esta Terblanche | played | Gillian Andrassy Lavery (1997-2001) |
| •Eugene J. Anthony | played | Stan Ulitowski (1988-1991) |
| •Eva La Rue | played | Dr. Maria Santos Grey (1993-1997; 2002-2005) |
| •Felicity LaFortune | played | Laurel Banning Dillon (#2) (1993-1996) |
| •Finola Hughes | played | Dr. Alexandra 'Alex' Devane Marick (1999-2001) / Anna Devane Hayward (2001-2003) |
| •Forbes March | played | Scott Chandler (#4) (1999-2000) |
| •Frances Heflin | played | Mona Kane (1970-1994) |
| •Francesca James | played | Kitty Shea Tyler (1972-1977) / Kelly Cole Tyler (1978-1981; 1983-1984; 1986; 1995) |
| •Francesca Poston | played | Donna Beck Tyler (#1) (1976) |
| •Fred Koehler | played | Oyster Cracker (1997-1998) |
| •Genie Francis | played | Ceara Connor Hunter (1990-1992) |
| •George Taylor (1) | played | Lord Geoffrey Ashford (1999-2000 / recurring / via flashbacks) |
| •Gil Rogers | played | Ray Gardner (1977-1979; 1982; 1993; 1994; 1999; 2001) |
| •Gilles Kohler | played | Gilles St. Claire (1985) |
| •Gillian Spencer | played | Daisy Murdoch Cortlandt (1980-1989; 1994) |
| •Grant Aleksander | played | Alec McIntyre (1993-1996) |
| •Greg Wrangler | played | Pierce Riley (#2) (1996) |
| •Gregory Chase | played | Dr. Charles 'Chuck' Tyler III (#2) (1972-1973) |
| •Gregory Gordon | played | Brian Bodine (#1) (1990-1991) |
| •Greta Lind | played | Katie Kennicott (1990-1992) |
| •Harriet Hall (1) | played | Brooke English (#3) (1981) |
| •Heather Stanford | played | Nina Cortlandt Warner (#2) (1984-1985) |
| •Hilda Haynes | played | Lois Sloane (1970) |
| •Hugh Franklin | played | Dr. Charles Tyler Sr. (1970-1983, 1995) |
| •Hugo Napier | played | Mike Roy (#2) (1984-1985) |
| •Hunter Tylo | played | Robin McCall (1985-1987) |
| •Ian Buchanan | played | Greg Madden (2005-2006) |
| •Ian Washam | played | Charlie Brent (#1) (1972-1976) |
| •Ingrid Rogers | played | Taylor Roxbury-Cannon (#1) (1992-1995) |
| •Irene Ng | played | An-Li Chen (#1) (1991) |
| •Ivan Shaw | played | Henry Chin (01/14/03-07/17/03) |
| •J. Eddie Peck | played | Dr. Joseph 'Jake' Martin Jr. (#5) (2000-2003) |
| •Jack Armstrong (1) | played | Greg Nelson (#4) (1986) |
| •Jack Magee (1) | played | Wally McFadden (#1) (1978-1980) |
| •Jack Scalia | played | Chris Stamp (2001-2003) |
| •Jack Stauffer | played | Dr. Charles 'Chuck' Tyler III (#1) (1970-1972) |
| •Jacqueline Boslow | played | Mary Kennicott Martin (#1) (1971) |
| •James Garde | played | Justin Carrier (1995; alternating) |
| •James Horan (1) | played | Creed Kelly (1987-1989) |
| •James Karen | played | Lincoln Tyler (#1) (1970) |
| •James Kiberd | played | Trevor Dillon (#2) (1989-2000) |
| •James McDaniel (1) | played | Mickey (1984) |
| •James O'Sullivan | played | Dr. Jeff Martin (#4) (1977-1979) |
| •James Patrick Stuart | played | Will Cooney Cortlandt (#2) (1989-1992) / Justin Carrier (1995; alternating) |
| •James Scott | played | Ethan Cambias (2004-2006) |
| •James Wiggins (1) | played | Jamal Wilson Cudahy (#1) (1993) |
| •Jane Elliot | played | Cynthia Preston Cortlandt (1984-1986) |
| •Janet Hubert-Whitten | played | Alice Dawson ((1999)) |
| •Jason Olive | played | Frank Hubbard (#2) (2002) |
| •Jean LeClerc | played | Jeremy Hunter (1985-1992; 2001) |
| •Jeffrey Byron | played | Dr. Jeff Martin (#5) (1986-1987) |
| •Jeffrey Carlson | played | Zarf (2006-2007) |
| •Jennifer Bassey | played | Marian Colby Chandler (C: 1998-2003 / R: 1983-1995, 2003-present) |
| •Jesse McCartney | played | Adam "J.R." Chandler, Jr. (#3) (1998-2001) |
| •Jill Larson | played | Opal Gardner Cortlandt (#2) (1989-2006, now recurring) |
| •Jim Fitzpatrick (1) | played | Pierce Riley (#1) (1995-1996) |
| •Joanna Miles | played | Ann Tyler Martin (#2) (1970-1971) |
| •Joey Vaughn Adams | played | Jaime Gibbons |
| •John Callahan (2) | played | Edmund (Gresham) Grey (1992-2005) |
| •John Danelle | played | Dr. Frank Grant (#2) (1971-1982) |
| •John Devlin | played | Jason Maxwell (#2) (1972-1973) |
| •John E. Dunn (1) | played | Thadeus 'Tad' Gardner Martin (#2) (1978-1981) |
| •John Furey | played | Lee Hawkins (1998) |
| •John James (1) | played | Dr. Jeff Martin (#6) (2006-2007) |
| •John Millard (1) | played | Louie Grecco (1994-1995) |
| •Jonathan Bennett (1) | played | Adam "J.R." Chandler, Jr. (#4) (2001-2002) |
| •Jordan Charney | played | Phillip Brent (#3) (1975) |
| •Joseph Barbara | played | Paolo Caselli (2000) |
| •Josh Duhamel | played | Leo du Pres (1999-2002) |
| •Josh Hamilton | played | Charlie Brent (#3) (1985) |
| •Judith Barcroft | played | Ann Tyler Martin (#3) (1971-1977) |
| •Julia Barr | played | Brooke English (#2) (1976-1981, 1982-2006) |
| •Justin Bruening | played | Jamie Martin (#2) (2003-2007) |
| •Karen Lynn Gorney (1) | played | Tara Martin Jefferson (#1; #3; #7) (1970-1974; 1976-1977; 1995) |
| •Karen Person | played | Galen Henderson (2) (1992-1993) |
| •Kari Gibson (1) | played | Dixie Cooney Martin (#1) (1988-1989) |
| •Kate Collins (1) | played | Natalie Marlowe Dillon (#1) (1985-1992; 1998; 2001) / Janet Marlowe Dillon (#1) (1991-1992) |
| •Kate Harrington | played | Kate Martin (#1) (1970) |
| •Katherine Kamhi | played | Pamela Kingsley (#1) (1980-1982) |
| •Kathleen Dezina | played | Estelle La Tour Sago (1977-1982) |
| •Kathleen Noone | played | Ellen Shepherd Dalton (1977-1989; 1995) |
| •Kathleen Rowe McAllen | played | Pamela Kingsley (#2) (1988) |
| •Kay Campbell (1) | played | Kate Martin (#3) (1970-1985) |
| •Keith Hamilton Cobb | played | Noah Keefer (1994-1996) |
| •Kelli Giddish | played | Di Henry (2005-2007) |
| •Kelli Taylor | played | Taylor Roxbury-Cannon (#2) (1995-1996) |
| •Kelly Ripa | played | Hayley Vaughan Santos (1990-2002) |
| •Ken Rabat | played | Paul Martin (#1) (1970-1972) |
| •Kevin Alexander | played | Adam "J.R." Chandler, Jr. (#2) (1992-1996) |
| •Kim Delaney | played | Jenny Gardner Nelson (1981-1984; 1994) |
| •Kim Hawthorne | played | Belinda Keefer (#1) (1995-1996) |
| •Kimberly Foster | played | Liz Sloan (1994-1995) |
| •Kristen Jensen (1) | played | Laurel Banning Dillon (#1) (1992-1993) |
| •Larkin Malloy | played | Travis Montgomery (#1; #3) (1987-1991; 1997; 1998; 2001) |
| •Larry Fleischman | played | Benny Sago (#1) (1976-1979) |
| •Larry Keith | played | Nick Davis (1970-1978; 1983-1984; 1988; 1991; 1993-1994; 1997) |
| •Laura Allen (1) | played | Laura Kirk English du Pres (#2) (2000-2002) |
| •Lauren E. Roman | played | Laura Kirk English du Pres (#1) (1995-1998) |
| •Lauren Holly | played | Julie Chandler (#2) (1986-1989) |
| •Laurence Lau (1) | played | Greg Nelson (#1; #3) (1981-1984; 1984-1986) |
| •Laurinda Barrett | played | Bitsy Davidson (#1) (1987) |
| •Lee Chamberlin (1) | played | Pat Baxter (1982-1991; 1995) |
| •Lee Godart | played | Kent Bogard (#2) (1992-1983) |
| •Leslie Uggams | played | Rose Keefer (1996) |
| •Linda Gibboney | played | Sybil Thorne (1979-1981) |
| •Lindsay Curran | played | Emily Ann Sago Martin (#1) (1982) |
| •Lindsay Price | played | An-Li Chen (#2) (1991-1993) |
| •Lisa Eichhorn | played | Elizabeth Carlyle (1987-1988) |
| •Lisa Wilkinson | played | Nancy Grant Fisher (#1) (1973-1984, 1995) |
| •Liz Vassey | played | Emily Ann Sago Martin (1988-1992) |
| •Lonnie Quinn | played | Will Cooney Cortlandt (#1) (1988-1989) |
| •Louis Edmonds | played | Langley Wallingford (AKA. Lenny Wlasuk) (1979-1995) |
| •Louise Shaffer | played | Goldie Kane (1988) |
| •Lynne Thigpen | played | Grace "Aunt Grace" Keefer (1993-2000) |
| •Marc Menard | played | Boyd Larraby (2002-2004) |
| •Marcus Patrick | played | Jamal Cudahy (2006) |
| •Marcy Walker | played | Liza Colby (#1; #3) (1981-1984; 1995-2004) |
| •Margaret Sophie Stein | played | Corvina Lang (1992-1993; 1994-1997) |
| •Marj Dusay | played | Vanessa Bennett Cortlandt (1999-2002) |
| •Mark Consuelos | played | Mateo Santos (1995-2002; recurring otherwise) |
| •Mark Dawson (1) | played | Ted Brent (1970-1971) |
| •Mark La Mura | played | Mark Dalton (1976-1985; 1986-1989; 1994-1995) |
| •Mark Pinter | played | Roger Smythe (2001-2002; recurring otherwise) |
| •Mary Fickett | played | Ruth Parker Martin (#1; #3; #5) (1970-1980; 1980-1996; 2000) |
| •Mary Lynn Blanks | played | Tara Martin Jefferson (#5) (1979-1981) |
| •Mathew St. Patrick | played | Adrian Sword (1998-2000) |
| •Matt Borlenghi | played | Brian Bodine (#2; #4) (1991-1993; 1996) |
| •Matt Servitto | played | Trask Bodine (#1) (1989-1990) |
| •Matthew Anton | played | Thadeus 'Tad' Gardner Martin (#1) (1973-1977) |
| •Matthew Cowles | played | Billy Clyde Tuggle (1977-1980; 1984; 1989-1990) |
| •Maurice Benard | played | Nico Kelly (1987-1989) |
| •Maximillian Alexander (1) | played | Juan Carlos Renato Ruiz de Vasquez (2003) |
| •Maxwell Caulfield | played | Pierce Riley (#3) (1996-1997) |
| •Melissa Leo | played | Linda Warner (1984-1985) |
| •Melody Anderson | played | Natalie Marlowe Dillon (#2) (1992-1993) |
| •Micah Alberti | played | James 'Jamie' Martin (#1) (2002-2003) |
| •Michael B. Jordan (1) | played | Reggie Montgomery (2003-2006) |
| •Michael Bersell | played | Bobby Martin (1970) |
| •Michael Brainard | played | Dr. Joseph 'Jake' Martin Jr. (#3) (1988-1991; 1994; 1995) |
| •Michael Lowry | played | Dr. Joseph 'Jake' Martin Jr. (#4) (1996-2000) |
| •Michael Minor (1) | played | Brandon Kingsley (1980-1982; 1988) |
| •Michael Nader | played | Dimitri Marick (#1) (1991-1999; 2000-2001) |
| •Michael Sabatino | played | Dr. Jonathan Kinder (1995-1996) |
| •Michael Scalera | played | Dr. Joseph 'Jake' Martin Jr. (#2) (1982-1988) |
| •Michael Tylo | played | Matt Connelly (#1) (1986-1988) |
| •Michael Woods | played | Kent Bogard (#1) (1981-1982) |
| •Michelle Trachtenberg | played | Lily Benton Montgomery #1 (1993-1996) |
| •Mike Minor (1) | played | Brandon Kingsley (1980-1982) |
| •Mitchell Ryan | played | Alex Hunter (1985-1986) |
| •Morgan Mullan | played | Colby Marian Chandler (#1) (2000 / Alternating Role) |
| •Nan-Lyn Nelson | played | Vivienne Roxbury-Cannon (1992-1995) |
| •Nancy Addison Altman | played | Marissa Rampal (1989 (#2) |
| •Nancy Frangione | played | Tara Martin Jefferson (#4; #6) (1977-1979, 1985) |
| •Natalia Cigliuti | played | Anita Santos Warner (#2) (2004-) |
| •Natalie Ross | played | Enid Nelson (1981-1986) |
| •Nicholas Pryor | played | Lincoln Tyler (#3) (1971) |
| •Nick Benedict | played | Phillip Brent (#2) (1973-1975; 1975-1977; 1988) |
| •Nicolas Coster (1) | played | Steven Andrews (1988-1989) |
| •Nicolas Surovy | played | Michael Roy (#1; #3) (1983-1984; 1988; 1998) |
| •Nicole Orth-Pallavicini | played | Marissa Rampal (#1) (1988) |
| •Nigel Reed | played | Wally McFadden (#2) (1980) |
| •Olga Sosnovska | played | Lena Kundera (05/2003-04/28/2004; recurring otherwise) |
| •Olivia Birkelund | played | Arlene Dillon Vaughan (#2) (1995-1996; recurring otherwise) |
| •Paige Rowland | played | Christine 'Kit' Montgomery Fisher (1998-1999) |
| •Paige Turco | played | Melanie 'Lanie' Cooney Rampal (1989-1991) |
| •Patricia Barry (1) | played | Peg English (1980-1981) |
| •Patricia Dixon | played | Caroline Dixon Grant (1975-1979) |
| •Patrick Skelton | played | Wally McFadden (#3) (1980 - 1981; 1984) |
| •Paul Dumont | played | Lincoln Tyler (#2) (1971) |
| •Paul Falzone | played | Jim Jefferson (1980-1981) |
| •Paul Gleason (1) | played | Dr. David Thornton (1976-1978) |
| •Paulette Breen | played | Claudette Flax Montgomery (#1) (1975) |
| •Peg Murray | played | Olga Swenson (1982-1996) |
| •Peter Bergman | played | Dr. Cliff Warner (1979-1987; 1988-1989) |
| •Peter Strong | played | Bob Georgia (1984-1985) |
| •Peter White (2) | played | Lincoln Tyler (#4) (1974-1981, 1984, 1986, 1995) |
| •Philip Amelio | played | Scott Chandler (#1) (1988-1991) |
| •Phyllis Lyons | played | Arlene Dillon Vaughan (#1) (1990-1993) |
| •Raúl Dávila | played | Hector Santos (1994-1996) |
| •Richard Hatch (1) | played | Phillip Brent (#1) (1971-1972) |
| •Richard Lawson | played | Lucas Barnes (1992-1994) |
| •Richard Roland | played | Jason Sheffield (1995-1996; 1997) |
| •Richard Shoberg | played | Tom Cudahy (1977-1995; recurring otherwise) |
| •Richard Van Vleet | played | Dr. Charles 'Chuck' Tyler III (#4) (1975-1984, 1989-1992, 1995) |
| •Robert Duncan McNeill (1) | played | Charlie Brent (#4) (1986-1988) |
| •Robert Gentry (3) | played | Ross Chandler (1983-1989) |
| •Robert Lupone | played | Zach Grayson (1984-1985) |
| •Robert Perault | played | Dr. Jeff Martin (#3) (1976-1977) |
| •Robin Christopher | played | Antoinette 'Skye' Patterson Chandler (#2) (1987-1991) |
| •Robin Mattson | played | Janet Marlowe Dillon (#2) (1994-2000) |
| •Robin Strasser | played | Dr. Christina Karras Martin (1976-1979) |
| •Roger Guenveur Smith | played | Miles Christopher (1997-1998) |
| •Rosa Nevin | played | Cecily Davidson Brent (1986-1989; 1994-1996) |
| •Rosalind Allen | played | Silver Kane (#1) (1987) |
| •Roscoe Born | played | Jim Thomasen (#1) (1997) |
| •Rosemary Prinz | played | Amy Parker Tyler (1970) |
| •Ross Petty | played | Eddie Dorrance (#1) (1978) |
| •Rudolf Martin | played | Anton Lang (1993-1996) |
| •Ruth Warrick | played | Phoebe Tyler Wallingford (1970-01/05/05) |
| •Sabine Singh | played | Greenlee Smythe (#2) (2007-2008) |
| •Samantha Eggar | played | Charlotte Devane (2000) |
| •Samuel Page | played | Ben 'Trey' Shepherd (2002-2003) |
| •Sandy Gabriel | played | Edna Thornton Ferguson (1977-1980, 1983-1986) |
| •Sara Hugh (1) | played | Tina Harding (1999-2001) |
| •Sarah Michelle Gellar | played | Kendall Hart (#1) (1993-1995) |
| •Schuyler Grant | played | Camille Hawkins (1998) |
| •Scott Kinworthy | played | Joshua Madden (#1) (06/2005-09/15/05) |
| •Scott Thompson Baker (1) | played | Craig Lawson (1991-1992) |
| •Season Hubley | played | Angelique Marick (1992-1994) |
| •Shane McDermott | played | Scott Chandler (#2) (1995-1996) |
| •Shari Headley | played | Mimi Reed (1991-1994; 2005-) |
| •Sidney Armus | played | Nigel Fargate (#1) (1976) |
| •Stacy Haiduk | played | Hannah Nichols (2007-2008) |
| •Stan Albers | played | Josh Waleski (later Elliot Freeman) (#1) (1988-1989) |
| •Stephanie Braxton | played | Tara Martin Jefferson (#2) (1974-1976) |
| •Stephanie Winters | played | Julie Chandler (#1) (1986) |
| •Stephen Caffrey (1) | played | Andrew Preston Cortlandt (1984-1986) |
| •Steve Fletcher (3) | played | Matt Connelly (#2) (1989) |
| •Steve Kanaly | played | Seabone Hunkle (1994) |
| •Susan Blanchard | played | Mary Kennicott Martin (#2) (1971-1975) |
| •Susan Plantt-Winston | played | Claudette Flax Montgomery (#2) (1977-1980) |
| •Susan Pratt | played | Barbara Montgomery (1987-1991, recurring otherwise) |
| •Susan Willis | played | Helga Voynitzheva (1991-1992) |
| •T. C. Warner | played | Kate 'Kelsey' Jefferson (1995-1998) |
| •Tanisha Lynn | played | Danielle Frye (2004-present) |
| •Tasia Valenza | played | Dottie Thornton Martin (#2) (1982-1986) |
| •Taylor Gildersleeve | played | Sydney Harris (2006) |
| •Taylor Miller | played | Nina Cortlandt Warner (#1; #4) (1979-1984; 1986-1989; 1994-1996) |
| •Teresa Blake | played | Gloria Marsh (1991-1998) |
| •Terrell Anthony | played | Thadeus 'Tad' Gardner Martin (#4) (1990) |
| •Terri Ivens (1) | played | Simone Torres (2001-2006; 2007) |
| •Theresa Saldana | played | Christina Vargas (1997) |
| •Tom Rosqui | played | Jason Maxwell (#1) (1972) |
| •Tom Wopat | played | Hank Pelham (2001-2002) |
| •Tom Wright (1) | played | Eugene Hubbard (1984-1985) |
| •Tommy J. Michaels | played | Tim Dillon (#1) (1991-1999) |
| •Tomy Dunster | played | Juan Pablo Renato Ruiz de Vasquez (2003-2004) |
| •Trent Bushey | played | David Rampal (1988-1991) |
| •Tricia Pursley Hawkins | played | Devon Shepherd McFadden (1977-1981; 1983-1984) |
| •Vanessa Bell Calloway | played | Yvonne Caldwell (1985) |
| •Vasili Bogazianos | played | Benny Sago (#2) (1980-1990) |
| •Vince Poletto | played | Tanner Jordan (1996-1997) |
| •Vincent Irizarry | played | David Hayward (1997-1998, 1998-2006) |
| •Warren Burton | played | Eddie Dorrance (#2) (1978-1979) |
| •Willi Burke (4) | played | Ruth Parker Martin (#2) (1980) |
| •William Christian | played | Derek Frye (1990-1996, recurring otherwise) |
| •William Mooney | played | Paul Martin (#2) (1972-1982; 1984-1985; 1995) |
| •William de Vry | played | Michael Cambias (2003 / 2004 / 2006) |
| •Winsor Harmon | played | Del Henry (#1) (1994-1995) |
| •Zen Gesner | played | Braden Lavery (1997-1998) |
