Spider-Man and Nova must help the Guardians of the Galaxy face a threat that has followed them to Earth.
Spider-Man’s dream of joining the Avengers becomes a nightmare when Loki switches bodies with the web-slinger, turning his new teammates against him.
Spider-Man and his friends team up with the Avengers to stop Loki and Doctor Octopus from destroying New York City with an army of Venomized monsters.
Spider-Man must team up with the super hero wanna-be Flash Thompson, when the Beetle wants them both destroyed.
To make matters worse, Flash had once again been Venomized but insists he's fighting for good.
Spider-Man wants to recruit Cloak and Dagger as new warriors for his S.H.I.E.L.D. team.