After the closure of Nonnatus House, the nuns and midwives finally move into their new premises. Sister Winifred arrives from the Mother House. Jenny is worried about new mother Merle’s mental state and the welfare of her baby who isn’t feeding properly. Dr Turner is worried that it could be something more serious.
Trixie is upset after Jenny is promoted, but the new Acting Sister has more important things to worry about after a mother-to-be reveals that the baby she is carrying is not her husbands and that the real father is black. Cynthia decides to give a lecture on natural childbirth, believing that it will help an overly anxious patient.
Sister Julienne gets a call from Holloway Prison where the Salvation Army, who normally offer midwifery for the inmates, have been struck down with influenza. She wants Trixie to help her at the prison and one of their patients called Stella, confesses that she’s scared that social services will think that she’s an unfit mother and take her baby away.
Jenny ends up having an eventful couple of days, beginning with trying to help a patient who is struggling to deal with her mother, an agoraphobic who hasn't been outside for at least 12 years. Alec wants Jenny to accompany her to Brighton for the weekend, leaving her wondering if his intentions are honourable.
Sister Julienne and Cynthia are getting donated clothing ready for charity. One parcel is set to go to St Gideon's, an institution which cares for those with disabilities and learning difficulties. Jacob, who suffers with cerebral palsy, helps Sally, who has Down’s syndrome, select a pretty cardigan to wear to the institution's annual dance. Following the dance, Sally’s mother discovers her feeling unwell and takes her to Nonnatus House to be looked at. The midwives find out that she is six months pregnant, which sees some difficult decisions needing to be made.
Tom and Fred are trying to spruce up an old bus outside of Nonnactus House which waylays the midwives who are due to set off on their rounds.
Cynthia is concerned that new mother Pamela is overly anxious, when Dr Turner arrives the mother and baby can't be found. Jenny returns and is seconded to The London were she soon begins to see cracks in the establishment. Chummy visits her mother in London. Tom cancels his first date with Trixie who tries to hide how she really feels about it.
Jenny pays a home visit to first time mother Jeanette and the two hit it off immediately, she is also introduced to Jeannette's cousin Philip. Chummy discovers her mother has discharged herself from hospital and her illness isn't getting any better. After a falling out, PC Noakes finding Lady Browne in great distress brings her to the home to be cared for in her final days.