On the way back to Hope Zion, Alex and Charlie get caught up in the aftermath of a shooting.
Alex must learn to stick up for herself and not be intimidated by Dawn (Charlie’s ex-wife) in order to work alongside her and perform a minimally invasive heart procedure to save a patient’s life. Meanwhile, Joel unlocks a mystery to a young girl’s disease, while getting some advice from Charlie, who is trying to figure out how to help his comatose patient come back from being a spirit. It’s a week of defying the odds at Hope Zion Hospital.
Alex is trying to get her life back to normal with Charlie and at Hope Zion Hospital, but with Charlie’s head in the clouds and the pressure to find her medical niche she’s struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife’s life, and in return, helps her find her calling.
The doctors at Hope Zion Hospital are forced to deal with people from their past as Alex, Charlie, and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path. Meanwhile, Zach is tested when the last person he wants to treat comes into his E.R. and a Season 1 patient returns with some difficult insight for Charlie and Alex.
Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion Hospital, while Joel connects with a disfigured refugee and tries to convince Dr. Dana Kinney to come back to operate on him. Meanwhile, a spirit who is familiar to many Hope Zion doctors shows up in the morgue when Charlie is about to do routine procedure.
After a young, healthy, and hunky fireman dies suddenly at Hope Zion Hospital, Alex must take the stand at Hope Zion's Morbidity and Mortality (M&M) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie deals with a nervous aspiring Nun, and Joel has to decide if he can be the man that comes through for Sonja.
Songs: Meaghan Blanchard -- Gotta Let
When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.
When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they’re forced to use only what’s around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.
When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja (guest star Erin Karpluk) deal with a patient of hers who’s been admitted to Hope Zion Hospital.
When Alex's brother is admitted to Hope Zion in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex.
Alex risks a dangerous surgery on a seemingly inoperable tumour to save a young boy's life. Meanwhile, Charlie struggles with the spirit of Alex's dead brother, Luke.
With one of the Hope Zion doctors’ life at risk, Alex must put her personal and professional reservations aside in order to perform a surgery that could save their life.
Songs: Don Brownrigg -- Just Breathe
Alex is surprised twice in one night – first when she realizes she's been tricked into a blind double date, and again when she has to rush her mystery man to the ER.
Alex witnesses a horrific accident on her way home from work and must return to the hospital to help the victims. Elsewhere, Charlie and Gavin attend a therapy session.
Songs: Travioso -- Lead Me Forward, Phoria -- Once Again
A couple is attacked by a bear, but Alex and Charlie think there's more to the story.
Charlie reaches a breaking point with a Spirit who won't leave him alone and Alex races against the clock to find an organ donor for a patient.
-- Still, Sam Roberts Band -- We're All In This Together
Charlie and Joel are pitted against one another by their patients. Complications occur during one of Dr. Kalfas' surgeries and Maggie finds herself stepping in even though she was only meant to be shadowing her mentor. Alex helps a patient out who in her old age believes she's living in a different era.
Night Beds -- Even If We Try, Jimmy Durante
-- I'll Be Seeing You
A member of staff is attacked. Alex has to ignore his diagnosis of an irregular heartbeat to care for the Great Randall. Charlies has to deal with the aftermath of the fight.
Songs: Zola Jesus
-- Avalanche (Slow), Roosevelt Nettles -- Drifting Heart, Matt Mays -- Madre Padre