Series 2 begins with Masters dealing with the ramifications of his disastrous presentation and being fired from the hospital. Meanwhile, Libby urges Masters to get another job; and Virginia fights off advances and innuendos stemming from the belief that she was the woman in Master's explicit film.
Betty's extortion continues as Masters starts his new job at Memorial Hospital and is told he can't continue to have Virginia as his secretary. Johnson doesn't know whether to get Masters to rehire her or to stay with DePaul as her condition worsens.
Virginia finds out about Masters' difficult childhood after they meet up at a hotel for a secret rendezvous.
Johnson and Masters are seen leaving a hotel together by Langham. Masters attempts bringing Johnson on board as his assistant as his new job. Betty tries to hide things from Gene.
Masters continues his work as the only white doctor in a black hospital, but it costs him his gynecology practice. Robert confronts Libby over the treatment of his sister. Betty and her former lover reunite. Johnson struggles to fix things with DePaul, who now knows what is going on with Masters.