While chasing the Fearsome Five, and escaping the Muddlefoots and their boring "Pelican's Island" birthday party for Honker, Darkwing is thrown into a giant cake - which serves as the universal portal between his world and the Negaverse. In the Negaverse, everything is the opposite of his world and Negaduck is supreme ruler, so Darkwing decides to use his new friends The Friendly Four to change things a bit, which Negaduck does not like one bit.