E! takes a look at the most intriguing relationships in the world of entertainment. Todays look at numbers 40-21.

40. Harrison Ford & Calista Flockhart
39. Sarah Jessica Parker & Matthew Broderick
38. Barbra Streisand & Don Johnson
37. Brad Pitt & Gwyneth Paltrow
36. Melissa Gilbert & Rob Lowe
35. Courteney Cox & David Arquette
34. Ozzy & Sharon Osbourne
33. David Beckham & Victoria Adams (Posh Spice)
32. Liza Minnelli & David Gest
31. Michael Jackson & Lisa Marie Presley
30. Sonny Bono & Cher
29. Madonna & Sean Penn
28. Ted Danson & Whoopi Goldberg
27. Bruce Willis & Demi Moore
26. R. Kelly & Aaliyah
25. Eminem & Kim Mathers
24. Lisa "Left Eye" Lopes & Andre Rison
23. Uma Thurman & Ethan Hawke
22. Jennifer Lopez & Sean "Puffy" Combs
21. Mike Tyson & Robin Givens