The gift's that Bo was born with have never been easy to understand; now aged 10 her powers are getting stronger still and much more dangerous. Tate, a wrongfully imprisoned prisoner who's serving time on death row, has lost all will to carry on until he's tasked with protecting Bo.
On the run toward Philadelphia, Tate decides to use Bo's talents to make some money at a casino. Meanwhile, Skouras uses his political connections to enlist the aid of the FBI, but not before hiring a backup tracker of his own.
Bo and Tate arrive in Manhattan, unaware that the FBI net is closing in on them. Bo takes the time to help a wealthy woman who is still mourning the loss of her son after decades.
Winter desperately looks for a way off Manhattan island for Bo and Tate while Bo has her own agenda, helping a couple find each other. Skouras prepares his own agent to find Bo.
Someone in Skouras' organization is leaking information to a blogger, which draws Bo and Tate to help them. The culmination of events leads to a confrontation between Bo and Joshua.
After being released from his ankle bracelet, Tate returns home to find answers why he ended up in prison for murder. After Joshua's defeat, Skouras looks for another telepath to turn into a weapon for the military.
After an intense confrontation with Zepeda leaves Bo vulnerable, Winter turns to guardians from Bo's past to protect her once again. As Tate and Winter take risky action to help Bo, revisiting the girl's past reveals surprising information about Channing's history. At Orchestra, Skouras pushes Sean to control his telekinetic abilities, with dangerous results.
Worried that Skouras has developed the ability to locate Bo, Winter sends Channing on a mission to infiltrate the Orchestra campus. Despite Winter's instructions to keep a low profile, Bo is compelled to help a family man who is in over his head.