| •Ron Howard | played | Richard J. "Richie" Cunningham (S01-S07) (167Eps.) |
| •Henry Winkler | played | Arthur Herbert "Fonzie" Fonzarelli (257Eps.) |
| •Marion Ross | played | Marion "Mrs. C" Cunningham (2Eps.) |
| •Anson Williams | played | Warren "Potsie" Weber (2Eps.) |
| •Don Most | played | Ralph Malph (S01-S07) (2Eps.) |
| •Erin Moran | played | Joanie Louise Cunningham/Arcola (S03-S09, S11; recurring otherwise) (2Eps.) |
| •Tom Bosley | played | Howard C. Cunningham (257Eps.) |
| •Al Molinaro | played | Alfredo "Al" Delvecchio (S05-S09) |
| •Scott Baio | played | Charles "Chachi" Arcola (S05-S09, S11) |
| •Lynda Goodfriend | played | Lori Beth Allen Cunningham (S08-S09; recurring in S05-S07) |
| •Cathy Silvers | played | Jenny Piccalo (S10; recurring in S08-S09) |
| •Ted McGinley | played | Roger Phillips (S10-S11; recurring in S08-S09) |
| •Linda Purl | played | Ashley Pfister (S10) |