Ed is injured in a shooting and a fall that leaves him crippled. While Ironside tries to determine who is responsible, Ed must decide whether to undertake a life-threatening operation.
A robber goes after two jewelry stores and somehow manages to tame the guard dogs. Suspicion initially falls on the dog trainer, Dunlap, who provided both dogs, but Ironside soon realizes that something more is involved... and gets a dog of his own to break the case.
Ironside goes on the air to discuss the murder of a 25-year-old art student in a public park... and panic the killer into making a mistake that will let the police get the evidence they need against him.
After getting his law degree, Mark takes on the case of a friend accused of murder. He soon becomes disillusioned when he discovers that the legal system is stacked against the man and wonders whether he has made the right choice for his life.
Songs: David and Marty Paich -- Darlin'
A pushy filmmaker accompanies Fran on patrol. Meanwhile, someone starts sending footage of women who are turning up dead... and the next one is of Fran.
A Japanese puzzle box is the only clue to a man's death in a seeming accident. His estranged daughter Jane suspects foul play and the case soon ends up in Ironside's lap.
While transferring a prisoner to Los Angeles, Ed ends up in jail when he confronts a pair of hostile beat cops. Rather than let Ironside bail him out, Ed insists on staying in jail in protest while he questions his own choice of career.
Ironside decides to reopen an old case he handled that may have put an innocent man in prison for seven years. However, the DA's office that convicted the man resists Ironside's efforts.
Songs: Carol Carmichael -- Now You're Gone
A man, Caesar, attaches an explosives belt to a scientist, Dr. Norman, and sends him to the Commissioner's office. Caesar then demands that the police release three men from prison or he'll detonate the belt.
Two rich young men stage a series of bizarre crimes and Ironside soon realizes that they're playing a game of chess using the city as their board.
Ironside comes to the aid of an old man whose daughter was murdered when the police don't have enough time to deal with the case.
Songs: Carol Carmichael -- Money Girl
Ed goes undercover to join a criminal gang suspected of plotting a kidnapping. When they pull it off, Ed tries to keep the victim alive while Ironside deals with her mother, a film star whose agent is worried about the kidnapping will affect his client's career.
While attending a conference in London, Ironside and Ed become involved with an assassination when Ed gets a glimpse of the killer... making him the next target. Ironside's efforts are hindered by an old friend, a superintendent who doesn't seem to want the Chief's help.
The Chief is sick in bed and sends Ed to check out a mysterious call from an old friend, Ted Ollinger. Ollinger is missing and the townspeople where he lives seem determined to make sure Ed doesn't find the man.
During a lavish party, someone takes a shot at the host, the editor of a popular gentleman's magazine. Ironside and Ed are in attendance and Ironside figures that the would-be killer is still somewhere on the ground.
While housesitting for a friend, Fran receives a series of increasingly disturbing anonymous calls. A local girl turns up dead and Ironside sets out to find the killer.
Rancher Aaron Clark is accused of murdering a former worker who set a fire. Aaron's much younger fiancé goes to Ironside for help, and Ironside explains that while he knew Aaron in the Navy, they weren't on the best of terms. Despite that, the Chief agrees to help and discovers that the small town is prejudiced against Aaron and the 19-year-old fiancé.
The Dancing Doll, a boat belonging to Ed's friend, is towed into the bay. His friend is gone leaving nothing behind but a bullet hole and blood, and the evidence soon suggests that the missing man was a mob killer.
Feminist writer Andrea Wolcott is shot at and Fran is assigned to protect her against further attacks. Meanwhile, Ed falls in love with Andrea's granddaughter, which endears him to neither Ironside nor Andrea.
Art thief Anthony Justin is released from jail, and is hired to commit a robbery... and takes advantage of the situation to engage Ironside, the man who caught him, in a battle of wits.
A mysterious thief commits an impossible robbery, breaking into a bank's safe deposit vault, and Ironside discovers that the one likely suspect may not be as guilty as he appears.
Ironside finds himself in a battle of wits when he's trapped in a bank with three robbers. They take Ironside and the other customers and staff hostage while awaiting for a payroll delivery truck to arrive.
After they get lost heading for a fishing trip, Ed and the Chief stop in a small town and get involved with a shooting at a motel run by a crooked gambler. The two officers soon get involved and Ironside sets out to help a couple get their money back in a high-stakes game of poker.