The Rockmores head off on a cross country trip, but Kenan and Kyra stow Kel away in the car. After the family makes camp for the night, the vacation quickly takes a turn for the spooky, when Kenan encounters a legendary ghost called the Headless Knight. When their car breaks down, Kenan and Kel go off in search of help, and end up at a sinister mansion that they may not leave alive.
One of "Crazy" Roger Rockmore's old friends is now a multi-millionaire with his own company. Kenan then uses the ploy of "quitting" to get a raise, but he ends up having to actually quit. When Kenan is looking for a new job at any large company, he finds one at Dim-Sum enterprises and goes for the interview, but when he switches resumes with another hopeful employee he ends up switching resumes with the soon-to-be executive vice president and must give a speech for his plans for the company.
When Kenan dances half-naked in his living room his mom's book club comes over. This prompts Kenan to try to get a bachelor pad for Kel and himself. While Kel is watching a version of the Newlywed Game called "The Honeymoon's Over", Kenan gets the idea of going on the show having Kel becoming Kellie Rockerferstien.
In a classic Kenan & Kel turn of events, the guys do a favor for Eric and pick up his girlfriend, Melissa from O' Hare Airport, only to pick up the wrong girl (named Melissa), knock her out cold, and give her amnesia. Now they must get Melissa to remember that she's Eric's girlfriend before he finds her gone - and before biker Mad Dog mauls the both of them for clobbering her with a suitcase.
Kenan wants to get his Drivers License, but his parents forbid him to get it until hes 18, so with Kels so-called "help" and Marc Cram's dad's car, he tries to learn, but puts off his science project in the process, causing him to sleep on his exam day - during the exam!
Kenan winds up with three dates for the same night, and tries to keep them from discovering each other.
Kenan gets the mistaken impression that he's adopted and sets out to the adoption agency to find out his truth because his parents own none of his baby pictures so he decides hes adopted. When at the agency, he finds out that another person was born on the same day, at the same time, in the same hospital, named Kevin Rockmore.
Kenan's senior prank on Principal Horn ends up getting him removed from the graduation exercises - and his parents and family best not know, or he's in deeper than usual!
Kenan and Kel take a trip to Hollywood in search of fame, stardom and David Alan Grier!
Kenan and Kel meet up with Britney Spears, David Alan Grier and end up making and unexpected appearance and the Julie Brown show.
Chris' brother comes to Chicago for a visit, bringing with him sibling rivalries and a ghoulish adventure for the Rockmores.
Kenan & Kel want the show to last forever so they make a show for the year 2099. Kel plays with the magic vacuum cleaner and makes Rodger disappear. Kenan and Kel try to fix the problem.
Kenan and Kel become masters of practical joking, until it starts making them suspicious of everything and everyone.
While reminiscing over clips of all their great memories from the show, Kenan and Kel get into a huge fight. Can the two stay friends long enough to get through this series finale?