| Name (Sort) | Character (Sort) | |
| •Harry Hamlin | played | Michael Kuzak (S01-S05) (106Eps.) |
| •Susan Dey | played | Grace Van Owen (S01-S06) (128Eps.) |
| •Corbin Bernsen | played | Arnie Becker (172Eps.) |
| •Jill Eikenberry | played | Ann Kelsey (172Eps.) |
| •Alan Rachins | played | Douglas Brackman Jr. (172Eps.) |
| •Michele Greene | played | Abby Perkins (S01-S05) (106Eps.) |
| •Jimmy Smits | played | Victor Sifuentes (S01-S05; recurring otherwise) (106Eps.) |
| •Michael Tucker | played | Stuart Markowitz (172Eps.) |
| •Susan Ruttan | played | Roxanne Melman (S01-S07) (150Eps.) |
| •Richard A. Dysart | played | Leland McKenzie (172Eps.) |
| •Blair Underwood | played | Jonathan Rollins (S02-S08) (150Eps.) |
| •Larry Drake | played | Benny Stulwicz (S03-S08; recurring previously) (130Eps.) |
| •Amanda Donohoe | played | Cara Jean "C.J." Lamb (S05-S06) (45Eps.) |
| •John Spencer | played | Tommy Mullaney (S05-S08) (89Eps.) |
| •Sheila Kelley (1) | played | Gwen Taylor (S06) (22Eps.) |
| •Cecil Hoffman (1) | played | Zoey Clemmons (S06) (22Eps.) |
| •Conchata Ferrell | played | Susan Bloom (S06) (22Eps.) |
| •Lisa Zane | played | Melina Paros (S07; recurring previously) (22Eps.) |
| •A. Martinez | played | Daniel Morales (S07-S08; recurring previously) (44Eps.) |
| •Alan Rosenberg (2) | played | Eli Levinson (S08; recurring previously) (22Eps.) |
| •Debi Mazar | played | Denise Ianello (S08) (22Eps.) |
| •Alexandra Powers | played | Jane Halliday (S08) (22Eps.) |