While on a train to El Paso to deliver a lecture at a conference, Jessica crosses paths with a woman who eventually disappears under mysterious circumstances. As she starts to investigate, Jessica soon discovers that the woman was in government protection after witnessing a whistle-blower get murdered to keep quiet about a top secret satellite code that has several fatal flaws in it and may have her own secrets to keep.
While in Virginia to attend a lecture by Dr. Cassandra Hawkins about a murder of a plantation owner in the 1860s by a slave named Sam Pinckney, Jessica soon discovers that she has a connection to the case, since she is a distant relative of Sarah McCullough, the slave’s owner. She soon teams up with Hawkins to set out to prove that Sam was set up and that the evidence brought against him was circumstantial. In a flashback, Sarah decides to investigate and eventually discovers that several guests who were at the man’s wedding may have wanted him dead and was willing to let Sam take the blame for it.
In the days following a party attended by numerous museum board members, Jessica gets involved with an investigation of several home invasion robberies that are connected to a highly sought after hairstylist that is rumored to leaving a popular beauty salon to start his own salon chain. When a scheming entrepreneur is found dead in the hairstylist’s chair, the Lieutenant in charge of the investigation suspects that the salon owner is the one who committed the murder, Jessica soon uncovers some clues that promptly make her suspect the victim’s wife and mistress are the ones who committed the crime.
As Laney Boswell is taking a walk with her friend and lawyer Terry Folger, she gets news that her husband died after losing control of his car and drove off a cliff. In the month since his death, Jessica arrives in Aspen to visit Laney and soon discovers that her friend is the prime suspect in her husband’s death and that a witness can prove that Laney was seen purchasing various tools to tamper with her husband’s car. Following the death of the witness, Jessica and Private Investigator Charlie Garrett team up with the local sheriff who is in charge of the investigation to prove Laney’s innocence and that her husband is actually alive and trying to commit insurance fraud.
After deciding to visit a friend in Gila Junction, Arizona, Jessica reluctantly gets involved with several investigations, one of which surrounds the death of a resident that recently found a large cache of money believed to have been stolen by an area truck-stop bandit and hid in the desert.
While in New Orleans to research a new novel, Jessica gets involved in an investigation of a series of murders that are the cause of voodoo curses. Following the death of a friend’s husband, Jessica soon discovers that his death seems to be apart of the other murders, especially when a voodoo doll is found at the scene of the crime. As she investigates his death, Jessica discovers that while the housekeeper and her daughter may have motives for wanting him dead, the man’s business associates got to him before the women could hurt him.
Suspicious deaths follow a nurse's return to Cabot Cove.
Jessica is in for an eerie trip to Ireland to visit a friend, when a young woman, who disappeared the previous year, is found dead in a dungeon not long before her arrival. After checking into her friend’s inn, Jessica soon discovers that an American businessman is trying to buy the inn in an attempt to turn it into first-class Americanized hotel. Thrown into the mix is another friend of Jessica’s, this one an inspector who is working undercover at the inn, possible illegal sales of priceless Irish artifacts, and the death of a hotel worker causes Jessica to stare death in the face when she gets locked in the same dungeon that Nan was found in.
As Rory and Eileen work to free Jessica from the dungeon, Eileen’s son Ian tries to secure funding to save his mother’s inn. Upon being saved, Jessica is able to convince her friends and the authorities that Nan was murdered and that her death has to do with covering up an intricate smuggling ring of Irish artifacts.
Ego clashes disrupt a movie shoot in Italy, but Jessica suspects sabotage when a crash occurs.
Jessica’s in New York to bid on an original Arthur Conan Doyle manuscript for the library board she is a member of. At the same auction, she crosses path with old friend Charlie Garrett, who is there to bid on a painting by an up and coming artist, unaware that it is covering up a stolen Degas painting and that several people want to get their hands on it. However, when the artist attempts to get it back before the auction is found dead, they team up with the police to locate the killer.
When Jessica arrives at the offices of a prominent ice cream company to pick up a substantial donation to her literacy fund, she is in for a surprise when the accountant she was to meet is found dead of an apparent suicide and the money gone. As Jessica sets out to prove that he was actually killed instead of taking his own life, another person, this time one of the top executives, is found dead of equally mysterious circumstances. It is through the course of helping the police with their investigation, it is soon discovered that both deaths are related to a secret that the one of the company’s co-owner tried to keep hidden.
After discovering that a rising Latin band is involved with the head of a shady recording company, Jessica works on getting an A&R from a big company to distribute their debut album. But when a petty thug who works for the shady recording company is murdered, Jessica has to work with the cops to find out what the motive was and who was behind his death.
When Jessica arrives in Cabot Cove to go to a benefit concert, she gets caught up in a murder investigation when the headliner is electrocuted during a sound check.
While working with a young editor on her new book, Jessica learns that she just read a manuscript by another author recounts with pinpoint accuracy of her kidnapping that happened years ago. When it looks like the authorities are reluctant to believe the girl’s story, Jessica offers to help her gain closure in what happened and is surprised at what she finds in their investigation.
While taping a PBS series at a Hollywood Studio, Jessica stumbles upon a murder mystery when a producer ends up dead after budget cuts forces her to cut some cast members of a popular sitcom.
When a puppet that Jessica created is adapted for television show, she arrives on the set to see her creation come to life. However, when several individuals have different ideas for the puppet and blackmail abounds as a result, Jessica has to solve a murder that occurred at the studio.
While visiting the lodge in the Grand Tetons, Jessica soon learns that the owner; an old friend and retired Colonel who is planning on running for public office, is being blackmailed to into calling off his bid for office. Things get sticker for him when a murder takes place and he is the prime suspect. It is up to Jessica and the man’s family to prove his innocence in the murder and in the past event that took place when he was still in the Army that he is being blackmailed for.
Following the death of a prominent businessman, Deputy Andy is accused of planting evidence against a shoe manufacturer he bought a house with numerous problems from. When the manufacturer ends up dead one night, Andy becomes the prime suspect in his murder. As a result, Jessica goes to work on clearing the deputy’s name.
As Jessica gets ready to go to Australia for a seminar, she gets a call from a lawyer from a small town who informs her that she may be the legal owner of valley is currently being leased by the local sheep farmers as grazing land. Upon her arrival in town, Jessica learns that the farmers are at odds with a visiting mining company who have drastic ideas over how to use the land, and that both groups are willing to kill to get their way.
Appointed honorary commodore of the World's Cup Regatta, Jessica finds herself witnessing an intense rivalry between two contestants Kyle Kimball and Ned Larkin. When in the days leading up to the contest Ned sustains an injury that results in his daughter Anne assuming the helm of his vessel, Kimball is less than thrilled about the change in crew. Later, when Kimball is found murdered and Anne is the prime suspect, Jessica sets out to prove that Anne is innocent in the death of her ex.
When Seth’s niece Amy arrives in Cabot Cove to get married to a local gardener, they soon get hassled by a local hood that happens to involved with the gardener’s ex-girlfriend. When her fiancé dies in a motorcycle accident on his way to see Amy at Jessica’s, Amy insists it wasn’t accidental. Later, when a local attorney is also murdered, Jessica has to find out how the deaths of both men are connected.
Upon her arrival in Atlanta for an Amateur Mystery Writers convention, Jessica gets involved with a FBI investigation when a lethal virus is stolen from a Biological Research Institute. Following the death of her friend Mark, Jessica starts an investigation of her own to discover the identity of his murderer and why they wanted him dead.
When a San Francisco radio station decides to change its format to be geared towards teenagers, the promoter of an up and coming DJ winds up dead and a friend of Jessica’s is the prime suspect. As a result, Jessica decides to use her investigative skills to prove her friend’s innocence and to find the real killer.