Mike, a boy-next-door type, is in awe of Euan, an overly confident womanizer. The two friends move into a New York City apartment complex home to celebrities and the wealthy. Things seem to be as good as they can get -- that is until Euan invites Mike's girlfriend, Liz, to live with them.
Mike and Liz both contract an STD and Mike blames Euan who he is sure is the cause of the infection. The condition puts a damper on Mike and Liz's anniversary as well as Euan's date.
Liz discovers Mike's hidden stash of XXX videos, and he's shocked when Liz is okay with it -- she even offers to watch them with him. But this seemingly good situation turns out to be a let-down for Mike. Euan tries to impress his jaded girlfriend.
Mike hits the town with Chau and Euan and turns down the advances of several woman in order to be faithful to Liz. However, Liz ends up kissing an old boyfriend that same evening.
Euan goes on a quest to find a steady girlfriend and finds Ginger, an artist who thinks she's leeching off of Euan. Status Quo's new clothing line makes him worry about his street cred. Meanwhile, Liz proves to Mike that skimpy clothing makes him uncomfortable.
Liz's sexy friend stays at the apartment for the weekend, getting Mike's hopes up that they might have a ménage à trois. Euan vows to remain celibate with his newest girlfriend, but lends his advice to Mike.
Mike's parents come to New York for a visit, giving Mike a chance to bond with his estranged father. Things start working out until Euan catches Mr. Platt with another woman.
Mike takes on a second job at Chau's restaurant to try to solve his money problems. When Euan offers to help Mike out, Mike refuses, so Euan pretends to get Mike a job at his firm when in reality Euan is the one paying him.
Euan is the subject of a hot rumor at work after a co-worker tells others that Euan is gay. Meanwhile, Mike is thrilled to meet Liz's unimpressive ex-boyfriend.
Mike learns about Liz's wild past and sets out to do things he missed out on when he was growing up. But things take an uncomfortable turn when after Mike and Liz have sex at the office, they discover there were surveilance cameras.
In desperate need of an enjoyable career, Mike heads to a career counselor. Meanwhile, Euan focuses his attention on his new B-movie actress neighbor.
Mike becomes increasingly comfortable with Liz, which leads to behavior that Liz isn't too fond of. Meanwhile, Euan avoids a woman who often breaks his heart and Status Quo works on a new song with Chau.
Mike stays at Lauren's for a while after he gets tired of living with Euan. To get back at Mike, Euan has Chau live in Mike's room.
Status Quo fires is posse when Mike and Euan tell him they're all "yes-men". However, when Status Quo invites the neighbors to be his new posse, he treats Euan like a slave instead of a friend.
Chau and Euan pretend to be rock stars to score women. Mike makes Liz angry when he proposes while drunk and forgets all about it.
Mike and Chau begin going to a gym where men often hang out in the nude. Meanwhile, Euan dates one of Liz's deaf friends, who turns out to be a lot meaner than everyone thinks.
Mike warns Euan to stay way from his attractive friend, telling him that she's his "backup girl" he has if things with Liz don't work out. Meanwhile, Chau tries to win a big-screen TV in a contest.
Liz sets up Chau with her bizarre roommate, which facilitates a very strange romance. Meanwhile, Euan lies about his age to date a 45 year-old woman.
Chau's new girlfriend becomes a hazard to him -- gets him involved in fights, which result in Chau getting beat up by strangers. Meanwhile, Euan, Mike and Liz dog-sit Status Quo's canine.
Euan is teased by Mike and Chau for having a foreskin. Euan makes an appointment with a urologist, who has a bizarre sense of humor when it comes to circumcision.
Euan worries about breaking up with one of MTV's The Real World cast members when he begins to think she'll bad-mouth him on national television. To get her out of his life, Euan sets up a plan to have Chau steal her away from him. Meanwhile, Mike lands a dream job of doing the sound for porn movies, but he becomes upset when he thinks Liz is hooking up with Status Quo while he works nights.
Mike decides it's time to break up with Liz, but Mike is thrown off when he beats him to it. But when the break-up sex is over the top, Mike changes his mind and tries to keep the relationship going. Meanwhile, Euan meets a woman who is more wild in bed than he is.
Euan and Status Quo meet a woman at a bar and fight each other for her attention. When they learn she has a twin, they compete to see who can sleep with both. Meanwhile, Mike bets on cockfights with Chau in order to make money for Liz's birthday present.
Mike wows the guys when he leaves the bar with the new apartment building tenant, Carmen Electra. However, Mike's new diet causes him to clog her toilet and enlists Euan and Chau to help clear it up.
Mike and Euan's urologist moves into their apartment building. They worry that the doctor will hurt their game, but soon find he attracts women.
Lindsay, Euan's date, announces to everyone that she wants to lose her virginity to Euan when she turns 18 at midnight. Upon hearing this, the gang have flashbacks to their first times.
Mike's high school friends come to visit, and their dorkiness makes Euan feel overly popular. Meanwhile, Status Quo and Liz have a date.
Mike and Euan switch accents to test whether it's the accent that lands women or if it's Euan. Meanwhile, Chau dates a crazy homeless woman.