| •Kristen Alderson | played | Starr Manning (2001-present) |
| •Melissa Archer | played | Natalie Buchanan (2001-present) |
| •Justis Bolding | played | Sarah Roberts (2007-present) |
| •Beth Ann Bonner | played | Talia Sahid (2007-present) |
| •Kathy Brier | played | Marcie McBain (2002-present) |
| •John Brotherton | played | Jared Banks (2007-present) |
| •Brandon Buddy | played | Cole Thornhart (2006-present) |
| •David Chisum (1) | played | Miles Laurence (2007-present) |
| •Kamar de los Reyes | played | Antonio Vega (1995-1998, 2000-present) |
| •Kassie DePaiva | played | Blair Cramer (#2) (1993-present) |
| •Michael Easton | played | John McBain (2003-present) |
| •Farah Fath | played | Gigi Morasco (2007-present) |
| •David Fumero | played | Cristian Vega (#2) (1998-2003, 2004-2005, 2005-present) |
| •Melissa Gallo | played | Adriana Cramer (#2) (2004-present) |
| •John-Paul Lavoisier | played | Rex Balsom (2002-present) |
| •Forbes March | played | Nash Brennan (2005-present) |
| •Erika Slezak | played | Victoria Lord Davidson (#2) (1971-present) |
| •Hillary Bailey Smith | played | Nora Hanen Buchanan (1992-present) |
| •Trevor St. John | played | Todd Manning (#2) (2003-present) |
| •Chris Stack | played | Michael McBain (2007-Present) |
| •Robin Strasser | played | Dorian Lord (#3) (1979-1987, 1993-2000, 2003-present) |
| •Tika Sumpter | played | Layla Williamson (2005-present) |
| •Jason Tam | played | Markko Rivera (2007-present) |
| •Brittany Underwood | played | Langston Wilde (2006-present) |
| •Jerry ver Dorn | played | Clint Buchanan (#2) (2005-present) |
| •Bree Williamson | played | Jessica Buchanan (#2) (2003-present) |
| •Robert S. Woods (3) | played | Bo Buchanan (1979-1986, 1988-present) |
| •Rod Browning | played | Ben Farmer (1974-1975) |
| •Brian Kerwin | played | Charlie Banks (2007-present) |
| •Adam O'Brien | played | Duke Buchanan ((#1); 1992) |
| •Alexander Blass | played | River Garvey Carpenter #1 (1993-1994 (Alternating Role)) |
| •Alexandra Neil | played | Paige Miller (#3) (2005-2007) |
| •Allan Miller | played | David Siegel ((#1); 1968-1972) |
| •Amanda Cortinas | played | Adriana Colón Cramer (#1) (2003) |
| •Andrea Evans | played | Tina Clayton Lord (#1) (1978-1981, 1985-1990) |
| •Anna Kathryn Holbrook | played | Lindsay Butler (1992) |
| •Anthony DeSando | played | Grant Noone (1996) |
| •Anthony George | played | Will Vernon (1977-1984) |
| •Ariella Jamnik | played | Starr Manning (#1) (1996-1998, (Alternating Role)) |
| •Arija Bareikis | played | Emily du Maura (1996) |
| •Arthur Burghardt | played | Dr. Jack Scott (1978-1980) |
| •Barbara Britton | played | Fran Craig Gordon #1 (1979-1980 (Played role until death)) |
| •Ben Watkins (1) | played | Jamal Pepper |
| •Brandon Routh | played | Seth Anderson (#1) (2001-2002) |
| •Brenda Brock | played | May McGillis / Brenda McGillis Grande, R. N. (1988 / 1988-1991) |
| •Bronwen Booth | played | Detective Andrea 'Andy' Harrison Gutherie Vega #1 (1989-1991) |
| •Brooke Alexander | played | Julia Michaels (2001) |
| •Bruce Michael Hall | played | Joey Buchanan (#6) (2003) |
| •Cady Huffman | played | Dr. Paige Miller Truman (#2) (2005-2006) |
| •Carol Potter | played | Beverly Wilkes (#1) (1979) |
| •Catherine Dent | played | Jancie Talbert (1997) |
| •Catherine Hickland | played | Lindsay Rappaport (1998-2005, recurring 2005-present) |
| •Charissa Chamorro | played | Sophia Pellegrino (1999-2001) |
| •Chase Browndorf | played | Frankie Holden #1 (1995-1996 (Alternating Role)) |
| •Christian Thomas Ashdale | played | John 'Jack' Cramer Manning #3 (2003-2004) |
| •Christina Chambers | played | Marty Saybrooke (#2) (2006-2007) |
| •Christopher Douglas (1) | played | Dylan Moody (1994-1997) |
| •Clarice Blackburn | played | Hattie Fredericks (1973-1974) |
| •Clint Ritchie (1) | played | Clint Buchanan (#1) (1979-1998) |
| •Cole Browndorf | played | Frankie Holden #1 (1995-1996 (Alternating Role)) |
| •Colm Meaney | played | Patrick London (1987-1988) |
| •Craig Sheffer | played | Ian Hayden (1982) |
| •Crystal Chappell | played | Maggie Carpenter (1995-1997) |
| •Dan Gauthier | played | Kevin Buchanan (#7) (2003-2006, 2007) |
| •Dana Barron | played | Michelle Boudin (1984-1985) |
| •Danielle Harris | played | Samantha Garretson (1985-1987) |
| •Danneel Harris | played | Shannon McBain (#1) (2004) |
| •Darlene Vogel | played | Melanie MacIver (2000-2001) |
| •David Aaron Baker (1) | played | Jeff Barnes #1 (1999) |
| •David Beecroft | played | Trent Chapin (1984-1985) |
| •David Gautreaux | played | Austin Buchanan (1989) |
| •David Tom | played | Paul Cramer (#2) (2004; 2005) |
| •Denny Albee | played | Dr. Peter Janssen #3 (1980-1982) |
| •Dina Andrews | played | Sarah Barry (1993-1996) |
| •Don Jeffcoat | played | Joey Buchanan (#5) (1997-2001) |
| •Donna Hanover | played | Elyse Hanson (2000) |
| •Dorie Barton | played | Beth Garvey (1993-1994) |
| •Doris Belack | played | Anna Wolek Craig (#1) (1968-1977 (Original Cast Member)) |
| •Eddie Alderson | played | Matthew "Matt" Buchanan (aka Matthew Rappaport) #3 (2001-) |
| •Eddie Karr (1) | played | Alonzo "Al" Holden (#5) (1994) |
| •Edward Sears | played | Chad Bennett (2002) |
| •Elisabeth Röhm | played | Dorothy Hayes (1997-1998) |
| •Eliza Clark | played | Jessica Lynn Buchanan Santi (#3) (1990) |
| •Elizabeth Keifer | played | Connie O'Neill Vernon (1984-1985) |
| •Ellen Bethea | played | Rachel "Ricki" Gannon #1 (1992-1995; 2000; 2001; 2002; 2005) |
| •Erika Page | played | Roseanne Delgado (#1) ((1998-2001) |
| •Erin Torpey | played | Jessica Buchanan (#1) (1990-2003) |
| •Ernest Graves | played | Victor Lord ((#1); 1968-1974) |
| •Evan Handler | played | Conrad Klein (1996) |
| •Fiona Hutchison | played | Gabrielle Medina (1987-1991; 2001-2004) |
| •Florence Anglin | played | Felicia (Late 1970s) |
| •Florencia Lozano | played | Téa Delgado (1997-2000, 2002) |
| •Frank Converse | played | Harry O'Neill (1984-1985, 1987) |
| •Frederick S. Backus | played | Brian (1995-1997) |
| •Gerald Anthony | played | Marco Dane / Dr. Mario Corelli (1977-1986; 1989-1990 / 1978) |
| •Gillian Spencer | played | Victoria "Viki / Blondie" Lord Riley Lord Buchanan Buchanan Carpenter Davidson (#1) (1968-1970 (Original Cast Member)) |
| •Gina Tognoni | played | Kelly Cramer Buchanan (#1) (1995-2002) |
| •Gloria Biegler | played | Connie Bensoncroft (1994) |
| •Grayson Hall | played | Euphemia Ralston (1982) |
| •Haviland Morris | played | Claire Baxter (2001-2003) |
| •Hayden Panettiere | played | Sarah "Flash" Roberts ((#3); 1994-1997) |
| •Heather Tom | played | Kelly Cramer (#3) (2003-2006) |
| •Humbert Allen Astredo | played | Bruno Weston (1979) |
| •Ilene Kristen | played | Georgina Whitman (#1) / Roxanne "Roxy" Balsom Holden (1982 / 2001-2004, recurring 2004-present) |
| •J. Evan Bonifant | played | Alonzo "Al" Holden (#3) (1991-1993) |
| •Jack Armstrong (1) | played | Kevin Lord Riley Buchanan (#7) (1994-1995) |
| •Jack Betts | played | Dr. Ivan Kipling (1979-1982; 1985) |
| •Jack Boscoe | played | John 'Jack' Cramer Manning #4 (2005-) |
| •Jacklyn Zeman | played | Lana McClain |
| •James DePaiva | played | Max Holden (#1) / (#3) (1987-1990 / 1992-2003) |
| •Jane Alice Brandon | played | Cathy Craig Lord #3 (1971-1972) |
| •Jane Badler | played | Melinda Cramer Janssen #2 (1977-1981; 1983) |
| •Jason Fischer (1) | played | Alonzo "Al" Holden (#6) (1994-1997) |
| •Jason Shane Scott | played | Will Rappaport (#1) (1998-2001; 2003; 2005, 2007) |
| •Jay Wilkison | played | Riley Colson (#1) (2003-2005) |
| •Jeff Bankert | played | Tyler McGillis #2 (1989-1990) |
| •Jeff Fahey | played | Gary Corelli (1982-1985) |
| •Jeff Pomerantz | played | Dr. Peter Janssen #1 (1976-1979; 1987) |
| •Jennifer Bransford | played | Georgie Phillips (1997-1998) |
| •Jensen Buchanan | played | Sarah Gordon Buchanan (#2) (1987-1990) |
| •Jeremy Slate | played | Chuck Wilson (1979-1987) |
| •Jessica Morris | played | Jennifer Rappaport (2001-2005) |
| •Jill Larson | played | Ursulla Blackwell (1988-1989) |
| •Jim Storm | played | Dr. Larry Wolek #2 (1968-1969) |
| •Joan Copeland | played | Gwendolyn Lord / Selma Hanen (1979 / 1995) |
| •Joanne Dorian | played | Victoria "Viki/Blondie" Lord Riley Lord Buchanan Buchanan Carpenter Davidson (#2) (1970-1971) |
| •Joe Lando | played | Jake Harrison (1990-1992) |
| •Joey Thrower | played | Kevin Lord Riley Buchanan (#5) (1991-1992) |
| •John Amos | played | Detective Johnson (1987-1988) |
| •John Bolger | played | John Sykes (1998-2001) |
| •John Loprieno | played | Cord Roberts (1986-1992; 1993-1997, 2007) |
| •John Martin (1) | played | Jon Russell (1986-1989; 1991-1992) |
| •Jon Hensley (1) | played | Brody Price (1985) |
| •Jonathan Brandis | played | Kevin Lord Riley Buchanan (#2) (1982) |
| •Josh Casaubon | played | Hugh Hughes (2005-2006) |
| •Joshua Coxx | played | Danny Wolek (1986-1987) |
| •Judith Chapman | played | Sandra Montaigne (1987) |
| •Judith McConnell | played | Eva Vasquez (1983) |
| •Julia Montgomery | played | Samantha Vernon (1976-1977, 1981) |
| •Kabir Bedi | played | Carlos Demitri (1986) |
| •Kale Browne | played | Samuel "Sam" Rappaport #1 (1998-2001) |
| •Kathleen Maguire | played | Anna Wolek Craig (#2) (1977-1978) |
| •Kathryn Breech | played | Karen Wolek Woleck #1 (1976-1977) |
| •Keith Bogart | played | Officer Drew Buchanan #1 (1988-1989) |
| •Kelly Bishop | played | Serena Wyman / Dr. Robbins (1989 / 1996) |
| •Ken Kenitzer | played | Kevin Lord Riley Buchanan (#8) (1995) |
| •Kerry Butler | played | Claudia Reston (2006-2007) |
| •Kevin Stapleton | played | Kevin Lord Riley Buchanan (#9) (1996-1998) |
| •Kim Zimmer | played | Bonnie Harmon / Echo DiSavoy (1978 / 1983) |
| •Kimberlin Brown (1) | played | Dr. Paige Miller Truman (#1) (2004-2005) |
| •Kirk Geiger | played | Kevin Lord Riley Buchanan (#6) (1992-1994) |
| •Kirk Raisch | played | Alonzo "Al" Holden (#1) (1988-1990, (Alternating Role)) |
| •Kristen Allen (1) | played | Tracy James (1985-1987) |
| •Laura Koffman | played | Cassie Carpenter ((#4); 1991-1999; 2001) |
| •Laurence Fishburne | played | Josh Hall (1973-1976) |
| •Laurence Lau (1) | played | Sam Rappaport (#2) (2001-2003) |
| •Leonie Norton | played | Julie Siegel ((#2); 1974-1976) |
| •Linda Dano | played | Rae Cummings (1978-1980, 1999-2004) |
| •Lisa Banes | played | Eve McBain (2004) |
| •Lisa Peluso | played | Billie Giordano / Gina Russo (#2) (1987 / 2001) |
| •Lori March | played | Adele Huddleston / Eugenia Lord (1977-1979 / 1987) |
| •Louise Sorel | played | Judith Sanders (1986-1987) |
| •Lynn Benisch | played | Meredith "Merrie" Lord Wolek #2 (1968-1973; 1987) |
| •Marie Masters | played | Helen Murdock (1982) |
| •Mark Arnold (1) | played | Rob Coronol #2 (1987-1989) |
| •Mark Brettschneider | played | Jason Webb (1991-1994) |
| •Mark Derwin | played | Ben Davidson (1999-2002; 2004) |
| •Mark Dobies | played | Daniel Colson (2005) |
| •Marva Hicks | played | Jacara Principal (1997-1998) |
| •Matthew Ashford | played | Drew Ralston (1982-1983) |
| •Matthew Metzger | played | Demerest "Duke" Buchanan #3 (2004-2006) |
| •Matthew Vipond | played | Kevin Lord Riley Buchanan (#4) (1990-1991) |
| •Maureen Anderman | played | Dr. Susannah Hanen (1995-1996) |
| •Meghan Rayder | played | Starr Manning (#2) (1998) |
| •Melissa Fraser Brown | played | Madison Kingston (2003) |
| •Mia Korf | played | Blair Daimler Cramer Buchanan Manning Manning Holden Laurence Manning (#1) (1991-1993) |
| •Michael Charles Roman | played | Alonzo "Al" Holden (#4) (1993-1994) |
| •Michael Magee (1) | played | Jeff Barnes #2 (1999-2000) |
| •Michael O'Hare | played | George Vasquez (1988) |
| •Michael Storm | played | Dr. Larry Wolek #3 (1969-) |
| •Michael Tipps | played | Alonzo "Al" Holden (#7) (2001) |
| •Morgan K. Melis | played | Kevin Lord Riley Buchanan (#1) (1976-1981) |
| •Nana Visitor | played | Georgina Whitman (#2) (1982) |
| •Nancy Barrett | played | Rachel Wilson Farmer / Assistant District Attorney Debra Van Druden (1974 / 1982) |
| •Nancy Lee Grahn (1) | played | Beverly Wilkes (1980-1982) |
| •Natalie Jamnik | played | Starr Manning (#1) (1996-1998, (Alternating Role)) |
| •Nathan Fillion | played | Joey Buchanan (#4) (1994-1997, 2008) |
| •Nathan Purdee | played | Hank Gannon (#1) (1992-2003) |
| •Nathaniel Marston | played | Alonzo Holden (#2) / Michael McBain (2001-2004 / 2003-2007) |
| •Nicole Orth-Pallavicini | played | Melinda Cramer Janssen #4 (1997; 2004) |
| •Obba Babatundé | played | Clay (2005) |
| •Olivia Birkelund | played | Sondra Hall (1991) |
| •Opal Alladin | played | Camilla Carr (1997) |
| •Pamela Payton-Wright | played | Addie Cramer (1991-1999, 2001) |
| •Patricia Elliot | played | Renee Buchanan (#2) (1987-2003, recurring 2003-present) |
| •Patricia Mauceri (1) | played | Carlotta Espinoza Vega (1995-1999; recurring 1999-present) |
| •Patricia Pearcy | played | Melinda Cramer Janssen #1 (1973-1974) |
| •Patrick Breen | played | Winslow Freeman (1996-1997) |
| •Paul Satterfield | played | Spencer Truman (2005-2007) |
| •Paul Tulley | played | Dr. Larry Wolek #1 (1968 (Original Cast Member)) |
| •Peter Bartlett | played | Nigel Bartholomew "Nige" Smythe #3 (1991-) |
| •Peter Brouwer | played | Dr. Alex Blair (1975) |
| •Peter Brown (1) | played | Charles Sanders, III #2 (1986-1987) |
| •Peter Parros | played | Ben Price (#2) (1994-1995) |
| •Philip Carey | played | Asa Buchanan / Butch Buchanan (1979-2007 / 1987) |
| •Phyllis Behar | played | Anna Wolek Craig (#3) (1978-1982) |
| •Raul Aronas | played | Julia Carerra (2004) |
| •Rebecca Boyd | played | Gina Russo #1 (2001) |
| •Reiko Aylesworth | played | Rebecca Lewis (1993-1994) |
| •Renée Goldsberry (1) | played | Evangeline Williamson (2003-2007) |
| •Richard Bekins | played | Dr. William Long (2004) |
| •Robert Raisch | played | Alonzo "Al" Holden (#1) (1988-1990, (Alternating Role)) |
| •Robin Christopher | played | Skye Chandler (1999-2001) |
| •Robyn Griggs | played | Stephanie Hobart ((#2); 1991-1992) |
| •Rod Brogan | played | Tripp Tucker (1991) |
| •Roger Howarth | played | Todd Manning (#1) (1993-1995; 1996-1998; 2000-2003) |
| •Roscoe Born | played | Mitch Lawrence (1985-1987, 2002-2003) |
| •Rose Alaio | played | Elaine Dixon (1987) |
| •Russ Anderson | played | Steven Holden (1986-1988) |
| •Ryan Buckley | played | Alonzo "Al" Holden (#2) (1990-1991, (Alternating Role)) |
| •Ryan Janis | played | Kevin Lord Riley Buchanan (#3) (1989-1990) |
| •Ryan Phillippe | played | Billy Douglas (1992-1993) |
| •Samuel Ball | played | Officer Drew Buchanan #3 (1998) |
| •Sandra P. Grant | played | Rachel Gannon (1996-1998) |
| •Scotty Bloch | played | Irma Weber (1999) |
| •Sean Buckley (1) | played | Alonzo "Al" Holden (#2) (1990-1991, (Alternating Role)) |
| •Shanelle Workman | played | Sarah "Flash" Roberts (#4) (2003-2004) |
| •Sharon Gabet | played | Melinda Cramer Janssen #3 (1987-1989) |
| •Shawn Christian | played | Ross Rayburn (2002) |
| •Shelly Burch | played | Delilah Ralston Buchanan Garretson (1982-1987; 1988-1989; 2001) |
| •Sherri Saum | played | Keri Reynolds (2001-2003) |
| •Simon Jones | played | Guy Armitage ((#1); 1997) |
| •Skip Burton | played | Dr. Peter Janssen #2 (1980) |
| •Sonia Satra | played | Barbara Graham (1998-1999) |
| •Starla Benford | played | Judith (1997-1998) |
| •Stephen Beach | played | Craig Longmire (2003) |
| •Stephen Bolster | played | Roger Landover (1979) |
| •Stephen Markle | played | Mel Hayes (1997-1999) |
| •Stephen Meadows (1) | played | Patrick London (1986-1987) |
| •Steve Austin (3) | played | Brian Kendall (1975-1978) |
| •Steve Richard Harris (2) | played | Seth Anderson (#2) (2002-2003) |
| •Steven Culp | played | Danny Wolek (1983-1984) |
| •Susan Batten | played | Luna Moody Holden (1991-1995; 1996; 2001; 2002; 2003-2004) |
| •Susan Haskell | played | Marty Saybrooke (#1) (1992-1997) |
| •Susan Misner | played | Grace Davidson ((#1); 1999) |
| •Tammy Amerson | played | Mari Lynn Dennison Coleman (1987-1990) |
| •Tania Elg | played | Olympia Buchanan (1980-1981) |
| •Ted Marcoux | played | Rob Coronol #1 (1984-1986) |
| •Terry Alexander (1) | played | Police Chief Troy Nichols (1990-1993) |
| •Thom Christopher (1) | played | Carlo Hesser / Mortimer Bern ((#1); 1990-1992, 1996-1997, 2005-/1992-1993, 1997) |
| •Thorsten Kaye | played | Patrick Thornhart ((#1); 1995-1997) |
| •Timothy Adams | played | Ron Walsh #1 (2003-2004; 2005) |
| •Timothy Gibbs | played | Kevin Lord Riley Buchanan (#10) (1998-2001) |
| •Timothy Stickney | played | R.J. Gannon (1994-2006) |
| •Tobias Truvillion | played | Vincent Jones (2006-2008; recurring 2008-present) |
| •Tom Berenger | played | Tim Seigel (1975-1976) |
| •Tommy Lee Jones | played | Mark Toland (1971-1975) |
| •Tonja Walker | played | Alex Olanov (1990-1997, 2007) |
| •Tracy Lindsey | played | Kelly Cramer (#2) ((2003) |
| •Tuc Watkins | played | David Vickers (1994-1996, 2003-2006, 2007) |
| •Ty Simpkins | played | John 'Jack' Cramer Manning #2 (2001-2002) |
| •Ty Treadway | played | Colin MacIver / Troy MacIver (2001-2002 / 2001-2003) |
| •Valorie Armstrong | played | Minna (1981-1983) |
| •Vanita Harbour | played | Rika Price (1990-1991) |
| •Victor Browne | played | Officer Drew Buchanan #2 (1996-1997) |
| •Walter Bobbie | played | William Davis Dawes (2003; 2004) |
| •Walter Gotell | played | Dirk Keller (1986) |
| •Will Bozarth | played | Nick Messina (2004-2005) |
| •Will Kempe (1) | played | Ian Armitage ((#1); 1997-1998) |
| •William Cox (1) | played | Tim Siegel (#1) (1970-1971) |
| •Wortham Krimmer | played | Rev. Andrew Carpenter ((#1); 1991-present) |
| •Yancey Arias | played | Emilio Gonzales (1994-1997) |
| •Yasmine Bleeth | played | LeeAnn Demerest Buchanan (1991-1993) |
| •Yorlin Madera | played | Cristian "Cris" Vega (#1) (1995-1998) |
| •Zachary Blass | played | River Garvey Carpenter #1 (1993-1994) |
