| •Erin Cardillo | played | Esme Vanderhesen (9/17/07-Present, previously recurring) |
| •Dylan Fergus | played | Noah Bennett (05/13/2005-present) |
| •Galen Gering | played | Luis Lopez-Fitzgerald (07/05/1999-present) |
| •Hannia Guillen | played | Paloma Lopez-Fitzgerald #2 (10/16/07-Present) |
| •Emily Harper | played | Fancy Crane (05/13/2005-present) |
| •Lindsay Hartley | played | Theresa Lopez-Fitgerald Crane (07/05/1999-present) |
| •Liza Huber | played | Gwen Hotchkiss Winthrop (#1) (07/05/1999-11/08/00, 10/16/02-present) |
| •James Hyde | played | Sam Bennett (07/05/1999-present) |
| •Eric Martsolf | played | Ethan Winthrop (#2) (07/08/2002-present) |
| •Ben Masters | played | Julian Linus Crane (07/08/1999-present) |
| •Juliet Mills | played | Tabitha Lenox (07/06/1999-present) |
| •Heidi Mueller | played | Kay Bennett Crane (#3) (10/24/2003-present) |
| •Blair Redford | played | Miguel Lopez-Fitzgerald (#3) (12/24/07-present) |
| •Tracey Ross | played | Dr. Eve Russell (07/05/1999-present) |
| •Melinda Sward | played | Pretty Crane (7/30/2007-Present) |
| •Eva Tamargo | played | Pilar Lopez-Fitzgerald (07/06/1999-present) |
| •Kim Johnston Ulrich | played | Ivy Winthrop Crane (07/08/1999-present) |
| •McKenzie Westmore | played | Sheridan Crane (07/05/1999-present) |
| •Bruce Michael Hall | played | Reese Durkee (08/00-05/02, recurring otherwise) |
| •Danica Stewart | played | Jessica Bennett Lester (#3) (07/10/2003-2007, recurring: 2007-present) |
| •Daphne Duplaix | played | Valerie Davis (12/16/2004-2006, recurring 2006-present) |
| •John Reilly | played | Alistair Crane (#2) (01/21/05-07/14/06, recurring: 2007-present) |
| •Justin Carroll | played | David Hastings (06/21/01-12/2/03, recurring otherwise) |
| •Kelli McCarty | played | Beth Wallace (09/6/02-8/30/04, recurring otherwise) |
| •Rodney Van Johnson | played | T.C. Russell (07/1999-12/2006, recurring: 2006-present) |
| •Victor McCay | played | Doc (10/03/01-03/22/02, recurred through 06/4/02) |
| •Adrian Bellani | played | Miguel Lopez-Fitzgerald (#2) (02/08/2006-09/07/2007) |
| •Adrian Wilson | played | Christopher Boothe (08/18/2005-08/13/2007) |
| •Brook Kerr | played | Whitney Russell Harris-Crane (07/05/1999-09/05/2007) |
| •Cathy Jenéen Doe | played | Simone Russell (#3) (07/23/2003-09/04/07) |
| •Charles Divins | played | Chad Harris-Crane (#2) (09/12/2002-08/28/07) |
| •James Stevenson | played | Jared Casey (7/21/2006-7/23/2007) |
| •Mark Cameron Wystracht (1) | played | Fox Crane (#2) (02/14/2006-09/07/2007) |
| •Silvana Arias | played | Paloma Lopez-Fitzgerald #1 (05/17/2004-08/15/2007) |
| •Amelia Marshall | played | Liz Sanbourne (10/301-02/17/06) |
| •Brandi Burkhardt | played | Siren (04/21/2006-09/25/2006) |
| •Justin Hartley | played | Fox Crane (#1) (12/17/02-02/10/06) |
| •Kyrie Maezumi | played | Maya Chinn (2006) |
| •Leigh Taylor-Young | played | Katherine Barrett Crane (05/14/2004-2006) |
| •Richard Steinmetz | played | Martin Fitzgerald (05/2004-9/2006) |
| •Sharon Wyatt | played | Rachel Barrett (12/30/05-04/03/06) |
| •David Bailey (1) | played | Alistair Crane (#1) (09/27/04-01/13/05) |
| •Christopher Douglas (1) | played | Antonio Brian Lopez-Fitzgerald (10/0101-06/24/04) |
| •Jack Krizmanich | played | John Hastings (12/31/01-02/11/04) |
| •Jesse Metcalfe | played | Miguel Lopez-Fitzgerald (#1) (07/05/1999-07/26/04) |
| •Kathleen Noone | played | Edna Wallace (01/27/03-08/30/04) |
| •Molly Stanton | played | Charity Standish / Zombie Charity (07/12/1999-7/22/04, Zombie Charity (2001-2002)) |
| •Ryan McPartlin | played | Hank Bennett (#2) (04/24/01-04/23/04) |
| •Alisa Reyes | played | Sydney Valentine (07/22/2003-09/24/2003) |
| •Deanna Wright | played | Kay Bennett (#2) (09/26/2000-10/06/03) |
| •Jade Harlow | played | Jessica Bennett (#2) (03/2000-07/08/03) |
| •Arturo Gil | played | Cecil (11/01/02-12/25/02) |
| •Donn Swaby | played | Chad Harris (#1) (09/23/1999-09/02) |
| •Josh Ryan Evans | played | Timmy Lenox (07/1999-08/02) |
| •Kacie Borrowman | played | Cracked Connie (09/09/2002-12/25/02) |
| •Natalie Zea | played | Gwen Hotchkiss Winthrop (#2) (11/14/00-10/04/02) |
| •Travis Schuldt | played | Ethan Winthrop (#1) (07/05/1999-07/03/02) |
| •Dalton James | played | Hank Bennett (#1) (08/26/1999-01/10/01) |
| •Lena Cardwell | played | Simone Russell (#1) (07/05/1999-04/16/01) |
| •Mary Elizabeth Winstead | played | Jessica Bennett (#1) (07/05/1999-03/28/00) |
| •Taylor Anne Mountz | played | Kay Bennett (#1) (07/05/1999-08/01/00) |
| •Dana Sparks | played | Grace Bennett / Faith Standish (07/5/99-12/02/03 / 1999) |
| •Jason Olive | played | Frank Lomax (08/9/99-09/23/99) |
