Guest Stars: Cress Williams as Richard Clayton | Laurie O'Brien as Denise Dembry | Lina Patel as Surgical Nurse | John Prosky as Newspaper Receptionist | Shirley Roeca as Mrs. Roeca | Trisha Simmons as Mrs. Geary | Derek Sitter as Usher | Peter Trencher as Anesthesiologist | Jennie Vaughn as Anita Langnoli | Al Vicente as Ramon Garcia | Seth T. Walker as Doctor | Vernee Watson-Johnson as Mrs. Redmond | Bobby Nish as Bobby | Adrian Neil as British Doctor | Naveen as Masood | Robert Knepper as Advantage Union Receptionist | Gerald McRaney as Coach Fontina | Stewart Bick as Otis Clayton | Luck Hari as Shanti Dervala | Frances Bay as Joan Hart | Sean Christopher Davis (1) as Mr. Ramsey | Alma Delfina as Dwayne Cochran | Katharine Leonard (1) as Theresa O'Riley | Denice Kumagai (1) as Kyoki | M. Evan Jensen as Pilot (as Evan Jensen) | Chad Haywood as Quarterback | Montrose Hagins as Ruth Clayton

Guest Stars: Dylan Walsh as Danny Gibson | Amy Stewart (1) as Nina Lombardi | Lou Richards as Detective | Andy Arness as Cable Car Rider (uncredited) | David Hornsby as Daniel Folmsbee | Stewart Bick as Eidenberg | Derek Sitter as Dumont | Gerald McRaney as Fontina | Vyto Ruginis as Tom Roback | Robert Knepper as Sean

Guest Stars: Michelle Noh as Connie Yu | Paul Norwood as Seth Braverman | Angela Oh as ER Nurse | Michael Purvis as Tyrell Washington | Kenna J. Ramsey as Jo Anderson (as Kenna Ramsey) | Jill Remez as Jill | Brady Smith as Jerry | Stephen Spacek as Bobby | Amy Stewart (1) as Nina Lombardi | Lawrence LeJohn as Dr. Stephen Flurgon | Alice Amter as Amira | Mae Whitman as Tory Redding | Dennis Cockrum as Gary Sanford | Dylan Walsh as Danny Gibson | Reed Diamond as Will Raymond | Clint Jung as Chan | Vyto Ruginis as Tom Roback | Octavia Spencer as Sheryl Washington (as Octavia L. Spencer) | Blaire Baron as Ellen Sanford | Elizabeth Alley as Maureen Braverman

Guest Stars: Kimberlee Peterson as Nina Lombardi | Dan Martin as Dwight | Leah Lail as Beatrice | Stephen Dunham as Sean | Andi Chapman as Will Raymond | Reed Diamond as Will Raymond | Amy Stewart (1) as Nina | Robert Knepper as Sean

Guest Stars: Michael York as | Jennie Vaughn as Anita Langnoli | John Rubinstein as Nguyen | Kevin Richardson (1) as Jesse | Bobby Nish as Bobby | Chase Masterson as Caroline Franklin | Robert Cicchini as Dr. Chan | Robert Bailey, Jr. as Eidenberg | Mark Moses as Nathan

Guest Stars: Red Buttons as Chick | Lisa Waltz as Juan | Jennie Vaughn as Anita Langnoli | Dianna Miranda as Isabella De La Torre | Gil Colon as Babu | P. J. Byrne as Dr. Whitby | Corbin Bernsen as Chick | Alice Amter as Amira | Ralph Meyering, Jr. as Dr. Boyd | Niecy Nash as Nurse

Guest Stars: Andrew J. Robinson as Jessie | Clint Jung as Dr. Chan | Lukas Behnken as Willie | Melissa Gilbert as Grace Bennett | Mark Moses as Nathan | Richard Lewis as Francis Weinod | Marina Malota as Ellen

Guest Stars: Steve Rifkin as Paramedic | David Brisbin as Beth | Sam Anderson as Fireman | Vyto Ruginis as Tom Roback | Christine Baranski as Dr. Terry Howland | Robert Knepper as Sean

Guest Stars: Hope Shin as Francie Ito #1 | Faith Shin as Francie Ito #2 | Walter Hong as Tech | Clare Carey as Georgia | Christina Hendricks as Claire | Robert Paul Lewis (6) as Expectant Father | Scott Paulin as Nguyen | Austin Chan as George Ito | Tara Karsian as Darlene | Kris Iyer as KJ | Francesca P. Roberts as Samantha Harkins | Alice Amter as Amira | Jernard Burks as Miles King | Jane Cho as Yalin Young | Pia C. Glenn as Georgia King | Jeannie Sakata as Nguyen | Lisa Tharps as Jenny Bevins

Guest Stars: Sharon Omi as Sumi | Kenneth Choi as Dennis | Charlie Westerman (1) as Becky Lochner | Peter Kanetis as Jerry Still | Stu Klitsner as Rabbi | Gary Richard Frank (1) as Magician | Max Jansen Weinstein as Rudy Rothman | Carlie Westerman (1) as | Karl Montgomery, Jr. (1) as Gilbert | Max Weinstein as Rudy Rothman | Josh Clark as Attending | Robert Knepper as Sean | Hallie Kate Eisenberg as Grace Rothman | Alma Delfina as Janine Rothman | Jennie Vaughn as Anita Langnoli | Jocelyn Rose as Lynette | Vyto Ruginis as Tom Roback | Lisa Edelstein as Mrs. Rothman

Guest Stars: Sharon Omi as Nurse Sumi | Kenneth Choi as Dennis | Todd Merrill as Neurologist | Gabriel Casseus as Dr. Boyd | Nicki Micheaux as Louise Altman | Bridget Simpson as Becky | Ralph Meyering, Jr. as Dr. Byod | Wendy Phillips as Mrs. Louise Altman | Dan Byrd as Curtis Altman | Ashleigh Olden as Sheryl | Harold Surratt as Janitor | Jocelyn Rose as Lynette

Writer: Lydia Woodward, Joseph Dougherty

Guest Stars: Barry Wiggins as Frank Haynes | Murray Rubinstein as Kevin Fernandez | Ralph Meyering, Jr. as Dr. Boyd | Dan Lundy as Ivan | Jack Klugman as Colleen Fernandez | Alex Kapp Horner as Fertility Doctor | Alia Shawkat as Tara Wegman | Julie Dretzin as Sharon Hess

Guest Stars: Michelle L. Shuffett as Clinic Patient | Jeremy Luc (1) as Alonzo | Nicole Garza as Becca | Natalie Garza as Emmy | Christian Camargo as Peter Witowski | Pat Asanti as Matson | Christine Baranski as Dr. Terry Howland

Guest Stars: Christian Camargo as Peter Witowski | Kenneth Choi as Dennis | Angela Sargeant as Second Attending

Guest Stars: Ralph Meyering, Jr. as Dr. Boyd

Guest Stars: Bailey Devlin as Matt | Dylan Ziegler as Adam Ross