Emergency doctor Drew is along with nurse Margaret serving the night shift. Because he doesn't want to miss a private date, he relies on inexperienced Dr. Edmunds to replace him. During this time Robert Keane, a heart attack patient, has been recently checked in. Dr. Edmunds must devote completely to the patient. While Margaret looks just after his concerned wife, Edmonds injects Keane with a wrong drug. The false treatment is deadly. When Dr. Drew comes back from his affair, he quickly recognizes the situation and tries to cover up the case along with Edmunds. Besides the chief of clinical emergency admission doesn't want the truth to come to light so Margaret is put under pressure to follow suit. But she doesn't like what she saw and decides to inform her uncle - forensic doctor Quincy.