Reno is looking for the killer who murdered a boy. During the investigation, he meets the young man's mother and decides to resume the hunting with her.
Reno seeks job as a cowboy in a ranch as part of his plan to find two brothers who brutally beat him, but his plan becomes complicated when he falls for the ex-wife of one of the men.
Old foe Lt. "Dutch" Dixon has turned into Reno's latest bounty when the corrupt cop goes on the lam after he's accused of murdering his partner.
Bobby receives a call from a crook who offers his testimony for a fat fee against Dutch Dixon.
Now that he has been convicted of Buzzy Burrell's murder and sent to a penitentiary, Reno is targeted for death by his fellow inmates.
Reno is thankful with an Elvis impersonator who saved him during a barroom brawl. Then Reno learns the man is the apparent heir to a fortune which stirs Bobby's interest in the case. A female journalist tracking Reno spots him and decides to turn him in.
Hideo Maruyama, Reno's old Martial Arts mentor, summons him to San Francisco when an Oriental mafia boss employs a Ninja killer to get rid of those who attempt to discredit him.
Reno finds that life may be anything but easy in the "Big Easy" when he pursues Leveaux, a murderous voodoo expert, down to New Orleans.
Reno is bound into infiltrating a rodeo to uncover a cattle-rustling scheme. Meanwhile, Bobby is fit to be tied when he can't even get a job as a peanut vendor.
Bobby and Reno follow Luke Landry, a former protege of Bobby's, who's running a hunting business in which fugitives are used as prey. While finding clues Reno is caught by Landry and sold as a prey for a trio of deadly hunters.
After Bobby's morally bankrupt banker departs hastily to Mexico with $150 million of Bobby's capital, the bounty hunter pleads Cheyenne and Reno to track down the embezzler before the FBI do.
A disgruntled man is killing any repo man who dares cross his path. He blames them for his ruin and the disappearance of his family. Reno tracks down the guy.
A dangerous arm dealer, Ty Waitly, throws a bomb into Sixkiller's office hurting Cheyenne. Bobby puts the blame on Reno for having arrived late. The discussion ends bitterly and Reno quits.
Reno starts to pursue D.B. Cooper after Bobby learns that the legendary fugitive is alive and prospering in a rural California town. Unfortunately, a rival bounty hunter overhears the news and wants the bounty for himself.
Bobby falls for a girl whose car he crashed while chasing a bounty, but the romance gets in the middle of a case and Reno distrusts Bobby's girlfriend.
Reno's close to arrest Sandman--an elusive assassin, who introduces thoroughbred horses to the Big Sleep--after getting himself hired at the stables where the killer last struck.
Reno comes to the assistance of his late fiancee's sister when a speedboat racer is found dead and she suspects there's something amiss.
In order to arrest mean mobster Tony Spano, Reno and Cheyenne must pretend they're honeymooners to get close to the crook, Bobby dislikes the plan involving such closeness.
A paroled rapist placed in another town by Bobby returns to his old ways and stalks young women.
A scared woman leaves her baby at Bobby's doorstep when she learns her convict husband broke out of prison and comes to know his never-seen baby.
Bobby receives the surprise visit of his stepmother and his roguish cousin, Brittney, and must run to protect them when a rapist begins to stalk Brittney.
A hidden UFO legend has come up and an old military friend asks Reno and Bobby to investigate.
A redheaded lady pretending to be a journalist abducts Reno in order to force him to marry her deranged sister. Bobby is hurt and lying in a hospital bed. Reno's only hope for rescue is Nathan, another bounty hunter.
Reno strangely wakes up in a world where he does not exist. Bobby is a hireling and Cheyenne is dead, but his fiancee is happily married to someone else.
Lucius Carabella is released from prison and has thoughts of doing in those that testified against him. He meets 'Dutch' who has a similar goal and enrolls a bounty to help. Sandy Carruthers, diploma in hand, applies for, and gets, a job, based on her purchase and completion of the Sixkiller video.
An abused wife gives her husband cop his deserved comeuppance and now she must run away from the dead man's partner while Reno is assigned to track her down.
An elaborate plot to incriminate Bobbie unfolds from a simple request to find a missing man.
Bobbie must find out if Bruce Cassidy, a convicted rapist/murderer on death row is really guilty before it is too late after the guy has sent him video with a forgiveness message for Bobbie.
Reno hunts for a kidnapped rock group star, but bringing him back alive is harder than finding him.
After Reno has a near death experience, the ghost of a man named Neil Kirby appears to Reno asking him to contact his wife and convince her of his innocence. This is not as easy as it sounds and the ghost helps Reno and Bobby catch the guilty parties.
Molly, a little girl shows Sandy a picture on a milk carton and begs her to help because it is her picture and she was kidnapped. This involves Bobby, who is attacked without knowing why, and Reno. They investigate on their own behalf.
Dan Travis, a Reno casino owner hires his old pal Bobby to catch the robbers who waylay high winning VIP gamblers on their way home. Reno joins the gang of robbers to find their contact inside the casino.
Melissa Dixon, Dutch's wife offers to help Bobby and Reno nail her husband. But the chance vanishes when Dutch discovers her game and forces her to set a trap for Reno.
Reno has run into a fugitive, believed dead, after he thwarts an armored truck robbery. Later he and Bobby learn about the Pipeline. The Pipeline is an organization that supplies criminals with a new identity, which includes removing the old one permanently. Reno accidentally discovers its existence and, with Bobby's help, attempts to destroy it. Meanwhile, Bobby is being audited by a persistent woman IRS agent.
Tony O'Malley, a pal and colleague of Bobby's, returns looking for a bank robber he calls the "Undiebomber" who threatens bank personnel with a fake bomb. When the robber catches him and demands ransom from Bobby, Bobby is not certain he wants to pay.
Dutch is blundering. Jack Hendricks wants him to have therapy with Dr. Judy Kaufman, a psychologist experienced with bereavement or take a leave. Someone else has knowledge of Mrs. Dixon's murder and further complicates life for Dutch, Reno and Bobby. It is a man specialized in security who holds a tape showing Dutch murdering his wife.
Bobby is blissed out because he has located a fugitive who blasted a chemistry building and inadvertently killed a scholar 25 years ago. Reno is not that keen.
A film producer hires Reno and Bobby to find his kickboxing heroine, who has vanished during the filming of a picture with the only clue, a card with a dragon emblem.
Bobby Sixkiller and Lake Bradshaw form a business society to promote 'active wear' for the bedroom and have sold the idea to Playpen Magazine which is run by Elaine Carlisle. The photo session is broken by two burglars who take the women hostage.
Reno bumps into a purported bloodsucker who stalks young runaways. Bobby says these creatures exist among his people, but are called something else and insists Reno uses his vampire kit.
Bobby is fidgety about his speech for receiving "Bounty of the Year" award. Several past cases are reviewed throughout the episode.
A jinxed prisoner helps Reno catch a exploitative sheriff who arranges fistfights for profit using prisoners.
Reno, Bobby and Sandy are on a stakeout to catch a mean, cold-blooded killer and robber who has a small daughter living with her mother, his ex-girlfriend. Sandy has brought a talking parrot along.
Donnie breaks out of prison to exact revenge on Reno. Marshall Jack suspects Dutch is hiding information and keeps a watch on the corrupt cop. Series finale.