Sabrina's Secret Life follows the adventures of the now-teenage witch, Sabrina Spellman. In the spin-off to Sabrina: the Animated Series, Sabrina is thirteen now, and in the 7th grade, which is in high school. Chloe has moved, along with Gem. Harvey still lives in Greendale, and attends Greendale High with Sabrina. Sabrina has not lost her crush of Harvey, which makes sense, since she dates him in Sabrina The Teenage Witch, the series that this series takes place directly before. Sabrina's new friend is Maritza, who regularly hangs out with Sabrina.
At Greendale High, there is a secret area, in which Sabrina trains her witch powers, and is instructed by teachers who are witches themselves.