The Man From U.N.C.L.E. was filmed in Hollywood, California, not New York City. The brown stone buildings of New York's East Side district were actually a studio back lot, with interiors all done in L.A.
On occasion, the show would use stock footage of world locations or custom shoot something in other parts of the country or world. But more than once, if a viewer is careful, the reflection of a palm tree or mountain can be seen in "New York" street windows.
A continuity flub is seen when Mr. Waverly hands Napoleon Solo a file. The wide shot shows the file transfer in a hallway vacant of all objects. But in the close-up, when the file is handed off, there's a telephone directly in the background when there was no phone or anything else in the hall.
At the end of the pilot episode, Robert Vaughn speaks directly to the camera, inviting viewers and advertisers to come back each week for more adventures.
In this short clip, Solo mistakenly informs the watcher that the U.N.C.L.E. headquarters is in New York's East Fifties, when in actuality, it's supposed to be the East Forties.
He also introduced actor Will Kuluva, who was to play his boss Mr. Allison. Kuluva would appear in the pilot only, turning over that role to Leo G. Carroll who would be featured as Mr. Waverly throught out the series.